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Contact-Tracing Outcomes Among Household Contacts of Fully Vaccinated Coronavirus Disease 2019 (COVID-19) Patients: San Francisco, California, 29 January–2 July 2021
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2021-12-17 , DOI: 10.1093/cid/ciab1042
Darpun D Sachdev 1 , Rilene Chew Ng 1, 2 , Madeline Sankaran 1 , Alexandra Ernst 3 , Katherine T Hernandez 1 , Venice Servellita 4 , Alicia Sotomayor-Gonzalez 4 , Juliet Stoltey 1 , Stephanie E Cohen 1 , Trang Quyen Nguyen 1 , Charles Y Chiu 4 , Susan Philip 1
Affiliation  

Background The extent to which vaccinated persons diagnosed with coronavirus disease 2019 (COVID-19) can transmit to other vaccinated and unvaccinated persons is unclear. Methods Using data from the San Francisco Department of Public Health, this report describes outcomes of household contact tracing during 29 January–2 July 2021, where fully vaccinated patients with COVID-19 were the index case in the household. Results Among 248 fully vaccinated patients with breakthrough infections, 203 (82%) were symptomatic and 105 were identified as the index patient within their household. Among 179 named household contacts, 71 (40%) contacts tested, over half (56%) were fully vaccinated and the secondary attack rate was 28%. Overall transmission from a symptomatic fully vaccinated patient with breakthrough infection to household contacts was suspected in 14 of 105 (13%) of households. Viral genomic sequencing of samples from 44% of fully vaccinated patients showed that 82% of those sequenced were infected by a variant of concern or interest and 77% by a variant carrying mutation(s) associated with resistance to neutralizing antibodies. Conclusions Transmission from fully vaccinated symptomatic index patients to vaccinated and unvaccinated household contacts can occur. Indoor face masking and timely testing of all household contacts should be considered when a household member receives a positive test result in order to identify and interrupt transmission chains.

中文翻译:

完全接种疫苗的 2019 年冠状病毒病 (COVID-19) 患者家庭接触者追踪结果:2021 年 1 月 29 日至 7 月 2 日,加利福尼亚州旧金山

背景 诊断患有 2019 年冠状病毒病 (COVID-19) 的已接种疫苗的人可以在多大程度上传播给其他已接种疫苗和未接种疫苗的人。方法 本报告使用旧金山公共卫生部的数据,描述了 2021 年 1 月 29 日至 7 月 2 日期间家庭接触者追踪的结果,其中完全接种疫苗的 COVID-19 患者是家庭中的指示病例。结果 在 248 名全面接种疫苗的突破性感染患者中,203 名(82%)出现症状,其中 105 名被确定为家庭内的指示患者。在 179 名家庭接触者中,71 名接触者(40%)接受了检测,超过一半(56%)已完全接种疫苗,二次发病率为 28%。在 105 个家庭中,有 14 个家庭(13%)怀疑有症状的、突破性感染的完全疫苗接种患者总体传播给家庭接触者。对 44% 完全接种疫苗的患者样本进行的病毒基因组测序显示,82% 的测序患者受到关注或感兴趣的变体感染,77% 的感染者携带与中和抗体抗性相关的突变。结论 可能会发生从完全接种疫苗的有症状指数患者传播给接种疫苗和未接种疫苗的家庭接触者的情况。当家庭成员收到阳性检测结果时,应考虑在室内佩戴口罩并及时对所有家庭接触者进行检测,以识别和中断传播链。
更新日期:2021-12-17
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