The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously expressed in human tissues, that orchestrates target RNA maturation and processing both in the nucleus and in the cytoplasm. A survey of known modulators of the RNA-HuR interactions is followed by a description of its structure and molecular mechanism of action – RRM domains, interactions with RNA, dimerization, binding modes with naturally occurring and synthetic HuR inhibitors. Then, the review focuses on HuR as a validated molecular target in oncology and briefly describes its role in inflammation. Namely, we show ample evidence for the involvement of HuR in the hallmarks and enabling characteristics of cancer, reporting findings from in vitro and in vivo studies; and we provide abundant experimental proofs of a beneficial role for the inhibition of HuR-mRNA interactions through silencing (CRISPR, siRNA) or pharmacological inhibition (small molecule HuR inhibitors).

人抗原 R (HuR) 蛋白是一种 RNA 结合蛋白，在人体组织中普遍表达，可在细胞核和细胞质中协调靶 RNA 的成熟和加工。在对已知的 RNA-HuR 相互作用调节剂进行调查之后，描述了其结构和分子作用机制——RRM 结构域、与 RNA 的相互作用、二聚化、与天然和合成 HuR 抑制剂的结合模式。然后，该综述着重于 HuR 作为肿瘤学中经过验证的分子靶标，并简要描述了其在炎症中的作用。也就是说，我们展示了充分的证据表明 HuR 参与了癌症的标志和使能特征，报告了体外和体内的发现学习; 我们提供了丰富的实验证据，证明通过沉默（CRISPR、siRNA）或药理学抑制（小分子 HuR 抑制剂）抑制 HuR-mRNA 相互作用的有益作用。