Here six novel imidazolinone derivatives have been synthesized and the compound 4b containing 5-para-methoxy-phenylidene and 2-thioalkylation terminal substitution with 3’-cyano-2’,6’-dimethylphenyl showed the best anti-HCV activity and the lowest cytotoxicity. Selectivity index (SI=CC₅₀/IC₅₀) for the 4b was determined as 36, indicating that compound 4b was highly selective towards HCV.

中文翻译：

---

一种具有5-亚芳基和2-取代巯基的新型咪唑啉酮衍生物作为强效抗丙型肝炎病毒化合物

本文合成了六种新型咪唑啉酮衍生物，其中含有 5-对甲氧基-亚苯基和 2-硫代烷基化末端被 3'-氰基-2',6'-二甲基苯基取代的化合物4b显示出最佳的抗 HCV 活性和最低的细胞毒性. 4b的选择性指数（SI=CC ₅₀ /IC ₅₀）确定为36，表明化合物4b对HCV具有高度选择性。