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The association between season, day length, and temperature on clinical outcomes after cryopreserved embryo transfer
Fertility and Sterility ( IF 6.7 ) Pub Date : 2021-12-20 , DOI: 10.1016/j.fertnstert.2021.11.014
Katharine F B Correia 1 , Leslie V Farland 2 , Stacey A Missmer 3 , Catherine Racowsky 4
Affiliation  

Objective

To investigate whether there is an association between season, temperature, and day length at oocyte retrieval and/or embryo transfer (ET) and clinical outcomes in frozen ET cycles.

Design

Retrospective cohort study.

Setting

Large academically affiliated research hospital.

Patient(s)

A total of 3,004 frozen ET cycles from 1,937 different women with oocyte retrieval and transfer between 2012 and 2017.

Intervention(s)

None.

Main Outcome Measure(s)

Implantation, clinical pregnancy, spontaneous abortion, and live birth.

Result(s)

Frozen ETs with oocyte retrieval dates in summer had 45% greater odds of clinical pregnancy (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.15–1.82) and 42% greater odds of live birth (OR, 1.42; 95% CI, 1.13–1.79) compared with those with oocyte retrieval dates in winter. A 41% greater odds of clinical pregnancy (OR, 1.41; 95% CI, 1.16–1.71) and 34% greater odds of live birth (OR, 1.34; 95% CI, 1.10–1.62) were observed among transfers with an average temperature at oocyte retrieval in the highest tertile (17.2–33.3 °C) compared with those in the lowest tertile (−17.2–6.7 °C). There were no consistent associations between clinical outcomes and day length at oocyte retrieval or between season, day length, or temperature at transfer of thawed embryos.

Conclusion(s)

Warmer temperatures at oocyte retrieval are associated with higher odds of clinical pregnancy and live birth among frozen ET cycles. The consistent associations seen with oocyte retrieval dates and the lack of associations observed with ET dates suggest that any seasonality effects on in vitro fertilization success are related to ovarian function and not uterine receptivity.



中文翻译:

冷冻保存胚胎移植后季节、日长和温度对临床结果的关系

客观的

调查取卵和/或胚胎移植 (ET) 的季节、温度和日长是否与冷冻 ET 周期的临床结果之间存在关联。

设计

回顾性队列研究。

环境

大型学术附属研究医院。

耐心)

2012 年至 2017 年间,来自 1,937 名不同女性的 3,004 个冷冻 ET 周期进行了卵母细胞提取和移植。

干预措施

没有。

主要观察指标)

植入、临床妊娠、自然流产和活产。

结果)

夏季取卵日期的冷冻 ET 临床妊娠几率增加 45%(优势比 [OR],1.45;95% 置信区间 [CI],1.15-1.82)和 42% 的活产几率(OR,1.42; 95% CI, 1.13–1.79) 与冬季取卵日期相比。在平均体温的转移中观察到临床妊娠的几率增加 41%(OR,1.41;95% CI,1.16-1.71)和活产的几率增加 34%(OR,1.34;95% CI,1.10-1.62)在最高三分位数(17.2-33.3°C)的卵母细胞检索与最低三分位数(-17.2-6.7°C)相比。临床结果与取卵时的日长之间或解冻胚胎移植时的季节、日长或温度之间没有一致的关联。

结论

取卵时温度较高与冷冻 ET 周期中临床妊娠和活产的几率较高有关。与卵母细胞提取日期一致的关联以及与 ET 日期缺乏关联表明,对体外受精成功的任何季节性影响都与卵巢功能有关,而不是与子宫容受性有关。

更新日期:2021-12-20
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