Riboflavin is one of the main micronutrients required for the human body for cellular respiration. It is the precursor of flavin mononucleotide and flavin adenine dinucleotide coenzymes crucial for the production of energy. The development of biotechnology has given rise to microbial procedures that strongly compete with the chemical synthesis approach and hence the fermentation process of riboflavin by microorganisms was initiated. Therefore, the main aim of this review is to investigate the production of riboflavin by Bacillus subtilis fermentation. The introduction of the microbial synthesis method has found that regulatory and structural genes involved in the synthesis of vitamin B2 are overexpressed, which has eventually enhanced the strain productivity and production of the vitamin via industrial fermentation. Using B. subtilis to synthesize riboflavin can reduce the production cost and increase the yield of riboflavin. The emergence of microbial synthesis methods has effectively increased the yield of riboflavin, and the study of the process of riboflavin synthesis by B. subtilis is of great significance for improving production, reducing costs and using renewable raw materials. © 2021 Society of Chemical Industry (SCI).

中文翻译：

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枯草芽孢杆菌生产维生素 B2（核黄素）

核黄素是人体细胞呼吸所需的主要微量营养素之一。它是对产生能量至关重要的黄素单核苷酸和黄素腺嘌呤二核苷酸辅酶的前体。生物技术的发展产生了与化学合成方法激烈竞争的微生物程序，因此启动了微生物发酵核黄素的过程。因此，本综述的主要目的是研究枯草芽孢杆菌产生核黄素的情况。发酵。微生物合成方法的引入发现，参与维生素B2合成的调控基因和结构基因过度表达，最终通过工业发酵提高了菌株的生产力和维生素的产量。利用枯草芽孢杆菌合成核黄素可以降低生产成本，提高核黄素的得率。微生物合成方法的出现有效地提高了核黄素的产量，研究枯草芽孢杆菌合成核黄素的工艺对于提高产量、降低成本和使用可再生原料具有重要意义。© 2021 化学工业协会 (SCI)。