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A metabolic biomarker predicts Parkinson’s disease at the early stages in patients and animal models
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2021 , DOI: 10.1172/jci146400
David Mallet 1 , Thibault Dufourd 1 , Mélina Decourt 2 , Carole Carcenac 1 , Paola Bossù 3 , Laure Verlin 4 , Pierre-Olivier Fernagut 2 , Marianne Benoit-Marand 2 , Gianfranco Spalletta 5 , Emmanuel L Barbier 1, 4 , Sebastien Carnicella 1 , Véronique Sgambato 6 , Florence Fauvelle 1, 4 , Sabrina Boulet 1
Affiliation  

Background. Care management of Parkinson’s disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD therefore represents a key step for developing therapies able to delay or slow down its progression.

中文翻译:

代谢生物标志物在患者和动物模型的早期阶段预测帕金森病

背景。帕金森病 (PD) 患者的护理管理目前仍然存在症状,主要是因为依赖于主要运动症状表达的诊断为时已晚。因此,早期检测 PD 代表了开发能够延迟或减缓其进展的疗法的关键步骤。
更新日期:2022-02-16
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