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Current practice and evolving concepts in septic shock resuscitation
Intensive Care Medicine ( IF 38.9 ) Pub Date : 2021-12-15 , DOI: 10.1007/s00134-021-06595-9
Jan Bakker 1, 2, 3, 4 , Eduardo Kattan 4 , Djillali Annane 5, 6 , Ricardo Castro 4 , Maurizio Cecconi 7, 8 , Daniel De Backer 9 , Arnaldo Dubin 10, 11 , Laura Evans 12 , Michelle Ng Gong 13 , Olfa Hamzaoui 14 , Can Ince 1 , Bruno Levy 15, 16, 17 , Xavier Monnet 18 , Gustavo A Ospina Tascón 19 , Marlies Ostermann 20 , Michael R Pinsky 21 , James A Russell 22 , Bernd Saugel 23 , Thomas W L Scheeren 24 , Jean-Louis Teboul 25 , Antoine Vieillard Baron 26, 27 , Jean-Louis Vincent 28 , Fernando G Zampieri 29, 30 , Glenn Hernandez 4
Affiliation  

Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. Even though large randomized, controlled trials have addressed fundamental aspects of septic shock resuscitation, many questions still exist. In this review, we will describe the current standards of septic shock resuscitation, but the emphasis will be placed on evolving concepts in different domains such as clinical resuscitation targets, adequate use of fluids and vasoactive drugs, refractory shock, and the use of extracorporeal therapies. Multiple research opportunities remain open, and collaborative endeavors should be performed to fill in these gaps.



中文翻译:

感染性休克复苏的当前实践和不断发展的概念

在过去的几十年中,对感染性休克的临床和病理生理学认识呈指数级进展,转化为与感染性休克相关的发病率和死亡率稳步下降。尽管大型随机对照试验已经解决了感染性休克复苏的基本方面,但仍然存在许多问题。在这篇综述中,我们将描述感染性休克复苏的当前标准,但重点将放在不同领域的不断发展的概念上,例如临床复苏目标、充分使用液体和血管活性药物、难治性休克和体外治疗的使用. 多种研究机会仍然开放,应开展合作以填补这些空白。

更新日期:2021-12-15
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