ABSTRACT

Recently, the need for effective antibacterial materials is growing day after day. Hydrogels with antimicrobial activities are strongly recommended in many biomedical applications. This work aims to prepare natural based nanocomposite hydrogel composed of N-vinyl pyrrolidone (NVP), acrylic acid (AAc) and pectin (PEC) embedded with silver nanoparticles (AgNPs). The prepared Poly(NVP/AAc/PEC/Ag) pH-sensitive nanocomposite hydrogel was characterized by gel (%), equilibrium swelling, FTIR, SEM, and XRD. Additionally, in order to confirm the incorporation of AgNPs within the nanocomposite hydrogel matrix during irradiation, TEM analysis was carried out. The AgNPs have average particles size 5.9 ± 1 nm for 10 kGy, 6.7 nm ± 2 for 20 kGy, and 8.9 ± 3 nm for 30 kGy, respectively. The XRD data are in good agreement with TEM analysis. The antibacterial activities of the selected Poly(NVP/AAc/PEC/Ag) nanocomposite hydrogel prepared at 30 kGy irradiation dose towards S. aureus, and E. coli has a higher antibacterial activity than other irradiation doses.

摘要

最近，对有效抗菌材料的需求与日俱增。在许多生物医学应用中强烈推荐具有抗菌活性的水凝胶。这项工作旨在制备由嵌入银纳米粒子 (AgNPs) 的 N-乙烯基吡咯烷酮 (NVP)、丙烯酸 (AAc) 和果胶 (PEC) 组成的天然纳米复合水凝胶。制备的 Poly(NVP/AAc/PEC/Ag) pH 敏感纳米复合水凝胶通过凝胶 (%)、平衡溶胀、FTIR、SEM 和 XRD 进行表征。此外，为了确认在照射过程中 AgNPs 在纳米复合水凝胶基质中的掺入，进行了 TEM 分析。AgNPs 的平均粒径分别为 5.9 ± 1 nm（10 kGy）、6.7 nm ± 2（20 kGy）和 8.9 ± 3 nm（30 kGy）。XRD 数据与 TEM 分析非常一致。