Aims To characterise the influence of primary open-angle glaucoma (POAG) and high myopia (HM) on the macular and choroidal capillary density (CD). Methods Two hundred and seven eyes were enrolled, including 80 POAG without HM, 50 POAG with HM, 31 HM without POAG and 46 normal controls. A fovea-centred 6×6 mm optical coherence tomography angiography scan was performed to obtain the CD of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris. Macular and choroidal CDs were compared among the groups and the association of CDs with visual field mean deviation (MD) was determined using linear regression models. Results Compared with normal eyes, SCP CD was decreased in the POAG without HM group (p<0.05), while DCP CD was significantly decreased in the HM without POAG group (p<0.05). Both SCP and DCP CDs were significantly decreased in the POAG with HM group (p<0.05). CD reduction occurred mainly in the outer rather than inner ring of the 6×6 mm scan size. In multivariate regression analysis, worse MD was associated with lower CD in the outer ring of the SCP in all the HM eyes (p<0.05). Conclusions POAG and HM reduced macular CD in different layers of the retinal capillary plexus and both particularly in the outer ring of the 6×6 mm scans. Furthermore, assessment of the CD in the outer ring of the SCP may facilitate the diagnosis of glaucoma in eyes with HM. Data are available upon reasonable request.

中文翻译：

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原发性开角型青光眼和高度近视患者的黄斑和黄斑下脉络膜微血管系统

目的 描述原发性开角型青光眼 (POAG) 和高度近视 (HM) 对黄斑和脉络膜毛细血管密度 (CD) 的影响。方法共纳入207只眼，其中POAG无HM 80只，POAG伴HM 50只，HM无POAG 31只，正常对照46只。进行以中央凹为中心的 6×6 mm 光学相干断层扫描血管造影扫描，以获得浅层毛细血管丛 (SCP)、深层毛细血管丛 (DCP) 和脉络膜毛细血管丛的 CD。在各组之间比较黄斑和脉络膜 CD，并使用线性回归模型确定 CD 与视野平均偏差 (MD) 的关联。结果 与正常眼相比，没有 HM 的 POAG 组的 SCP CD 减少（p<0.05），而没有 POAG 的 HM 组的 DCP CD 显着减少（p<0.05）。POAG 与 HM 组中的 SCP 和 DCP CD 均显着降低 (p<0.05)。CD 减少主要发生在 6×6 mm 扫描尺寸的外环而不是内环。在多变量回归分析中，较差的 MD 与所有 HM 眼中 SCP 外环的较低 CD 有关 (p<0.05)。结论 POAG 和 HM 减少了视网膜毛细血管丛不同层的黄斑 CD，尤其是 6×6 mm 扫描的外环。此外，评估 SCP 外环中的 CD 可能有助于诊断 HM 眼中的青光眼。可根据合理要求提供数据。在所有 HM 眼中，较差的 MD 与 SCP 外环中较低的 CD 相关（p < 0.05）。结论 POAG 和 HM 减少了视网膜毛细血管丛不同层的黄斑 CD，尤其是 6×6 mm 扫描的外环。此外，评估 SCP 外环中的 CD 可能有助于诊断 HM 眼中的青光眼。可根据合理要求提供数据。在所有 HM 眼中，较差的 MD 与 SCP 外环中较低的 CD 相关（p < 0.05）。结论 POAG 和 HM 减少了视网膜毛细血管丛不同层的黄斑 CD，尤其是 6×6 mm 扫描的外环。此外，评估 SCP 外环中的 CD 可能有助于诊断 HM 眼中的青光眼。可根据合理要求提供数据。