OBJECTIVE About half of individuals seeking treatment for borderline personality disorder (BPD) present with co-occurring posttraumatic stress disorder (PTSD). However, therapies that have been proven efficacious for simultaneously treating the full spectrum of core symptoms in patients with a dual diagnosis of BPD + PTSD are lacking. METHOD This is a subgroup analysis from a randomized controlled trial (registration number DRKS00005578) which compared the efficacy of two treatment programs, dialectical behavior therapy for PTSD (DBT-PTSD) versus cognitive processing therapy (CPT). Specifically, the present analysis was carried out in 93 women with a dual diagnosis of BPD + PTSD (Diagnostic and Statistical Manual for Mental Disorders; DSM-5). Outcome evaluations included the Clinician-Administered PTSD Scale, the Borderline Symptom List, and validated scales assessing dissociation, depression, and global functioning. The primary analysis was based on the intent-to-treat population, using mixed models. RESULTS Both PTSD and BPD symptoms significantly decreased in both treatment groups. For PTSD symptoms, pre-post effect sizes were d = 1.20, 95% confidence interval (CI): [0.80-1.58] in the DBT-PTSD group and d = 0.90, 95% CI: [0.57-1.22] in the CPT group; for BPD symptoms, they were d = 1.17, 95% CI: [0.77-1.55], and d = 0.50, 95% CI: [0.20-0.79], respectively. Between-group comparisons significantly favored DBT-PTSD for improvement in symptoms of PTSD, BPD, and dissociation. Between-group differences regarding depression and global functioning were not significant. CONCLUSION Both DBT-PTSD and CPT emerged as promising treatment options for simultaneously addressing the full spectrum of core symptoms in patients diagnosed with BPD + PTSD. Differential efficacy was in favor of DBT-PTSD as participants randomized to the DBT-PTSD arm improved more with respect to both their BPD and PTSD symptoms. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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治疗患有边缘型人格障碍和与童年虐待相关的创伤后应激障碍双重诊断的成年人：随机临床试验的结果。

目标 寻求治疗边缘型人格障碍 (BPD) 的人中约有一半同时患有创伤后应激障碍 (PTSD)。然而，缺乏已被证明可有效同时治疗 BPD + PTSD 双重诊断患者的全部核心症状的疗法。方法 这是一项随机对照试验（注册号 DRKS00005578）的亚组分析，该试验比较了两种治疗方案的疗效，辩证行为疗法治疗 PTSD (DBT-PTSD) 与认知加工疗法 (CPT)。具体而言，本分析是在 93 名双重诊断为 BPD + PTSD（精神疾病诊断和统计手册；DSM-5）的女性中进行的。结果评估包括临床医生管理的 PTSD 量表、临界症状列表、以及评估分离、抑郁和整体功能的有效量表。主要分析基于意向治疗人群，使用混合模型。结果 两个治疗组的 PTSD 和 BPD 症状均显着减少。对于 PTSD 症状，前后效应大小为 d = 1.20，95% 置信区间 (CI)：DBT-PTSD 组中的 [0.80-1.58] 和 d = 0.90，95% CI：CPT 中的 [0.57-1.22]团体; 对于 BPD 症状，它们分别为 d = 1.17, 95% CI: [0.77-1.55] 和 d = 0.50, 95% CI: [0.20-0.79]。组间比较显着有利于 DBT-PTSD 改善 PTSD、BPD 和分离的症状。关于抑郁症和整体功能的组间差异不显着。结论 DBT-PTSD 和 CPT 都成为有希望的治疗选择，可同时解决诊断为 BPD + PTSD 的患者的所有核心症状。差异疗效​​有利于 DBT-PTSD，因为随机分配到 DBT-PTSD 组的参与者在 BPD 和 PTSD 症状方面的改善更多。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。