Objective To correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with best vitelliform macular dystrophy (BVMD). Methods and analysis This is a retrospective case series of consecutive patients with molecularly confirmed BEST1- associated BVMD. OCT scans were reviewed for lesion status and presence of subretinal pillar, focal choroidal excavation (FCE), intraretinal fluid or atrophy. Available OCT angiography images were used to evaluate for the presence of choroidal neovascularisation (CNV). These features were then correlated with BCVA and Gass lesion type. Results 95 eyes from 48 patients (mean age 38.9 years, range 4–87) were included. The presence of a pillar (24.2%), FCE (20.0%) and atrophy (7.4%) were associated with poor BCVA (p<0.05). Gass lesion type 1 eyes were correlated with good BCVA (LogMAR <0.4) whereas type 5 eyes had poor BCVA (LogMAR >0.4). Among 65 eyes with longitudinal data (mean follow-up 5.1 years), 7 eyes (10.8%) reverted from higher to lower Gass lesion type; of these, 4 eyes (57.1%) had CNV responsive to intravitreal anti-vascular endothelial growth factor treatment. Conclusion OCT-based structural features are readily identifiable in patients with BVMD and have prognostic importance due to their correlation with BCVA. Data are available upon reasonable request. Not applicable.

中文翻译：

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最佳卵黄样黄斑营养不良中 OCT 特征与视力和 Gass 病变类型的相关性

目的 将光学相干断层扫描 (OCT) 所见的结构特征与最佳卵黄样黄斑营养不良 (BVMD) 患者的最佳矫正视力 (BCVA) 和 Gass 病变类型相关联。方法和分析 这是一个回顾性病例系列，涉及分子证实的 BEST1 相关 BVMD 的连续患者。审查 OCT 扫描的病变状态和是否存在视网膜下柱、局灶性脉络膜开挖 (FCE)、视​​网膜内积液或萎缩。可用的 OCT 血管造影图像用于评估脉络膜新生血管 (CNV) 的存在。然后将这些特征与 BCVA 和 Gass 病变类型相关联。结果包括来自 48 名患者（平均年龄 38.9 岁，范围 4-87）的 95 只眼。支柱 (24.2%)、FCE (20.0%) 和萎缩 (7.4%) 的存在与较差的 BCVA 相关 (p<0.05)。气体病变 1 型眼与良好的 BCVA（LogMAR <0.4）相关，而 5 型眼的 BCVA 较差（LogMAR >0.4）。在有纵向数据的65只眼中（平均随访5.1年），7只眼（10.8%）从较高的Gass病变类型转为较低的Gass病变类型；其中，4 只眼 (57.1%) 的 CNV 对玻璃体内抗血管内皮生长因子治疗有反应。结论 基于 OCT 的结构特征在 BVMD 患者中很容易识别，并且由于它们与 BCVA 的相关性而具有预后重要性。可根据合理要求提供数据。不适用。1%) 的 CNV 对玻璃体内抗血管内皮生长因子治疗有反应。结论 基于 OCT 的结构特征在 BVMD 患者中很容易识别，并且由于它们与 BCVA 的相关性而具有预后重要性。可根据合理要求提供数据。不适用。1%) 的 CNV 对玻璃体内抗血管内皮生长因子治疗有反应。结论 基于 OCT 的结构特征在 BVMD 患者中很容易识别，并且由于它们与 BCVA 的相关性而具有预后重要性。可根据合理要求提供数据。不适用。