Clinical Gastroenterology and Hepatology ( IF 12.6 ) Pub Date : 2021-12-07 , DOI: 10.1016/j.cgh.2021.12.002 Michael H Le 1 , Yee Hui Yeo 2 , Xiaohe Li 3 , Jie Li 4 , Biyao Zou 5 , Yuankai Wu 6 , Qing Ye 7 , Daniel Q Huang 8 , Changqing Zhao 9 , Jie Zhang 10 , Chenxi Liu 10 , Na Chang 10 , Feng Xing 9 , Shiping Yan 10 , Zi Hui Wan 11 , Natasha Sook Yee Tang 11 , Maeda Mayumi 1 , Xinting Liu 12 , Chuanli Liu 4 , Fajuan Rui 4 , Hongli Yang 4 , Yao Yang 10 , Ruichun Jin 13 , Richard H X Le 1 , Yayun Xu 4 , David M Le 1 , Scott Barnett 1 , Christopher Donald Stave 14 , Ramsey Cheung 15 , Qiang Zhu 10 , Mindie H Nguyen 5
Background & Aims
The increasing rates of obesity and type 2 diabetes mellitus may lead to increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine the current and recent trends on the global and regional prevalence of NAFLD.
Methods
Systematic search from inception to March 26, 2020 was performed without language restrictions. Two authors independently performed screening and data extraction. We performed meta-regression to determine trends in NAFLD prevalence.
Results
We identified 17,244 articles from literature search and included 245 eligible studies involving 5,399,254 individuals. The pooled global prevalence of NAFLD was 29.8% (95% confidence interval [CI], 28.6%–31.1%); of these, 82.5% of included articles used ultrasound to diagnose NAFLD, with prevalence of 30.6% (95% CI, 29.2%–32.0%). South America (3 studies, 5716 individuals) and North America (4 studies, 18,236 individuals) had the highest NAFLD prevalence at 35.7% (95% CI, 34.0%–37.5%) and 35.3% (95% CI, 25.4%–45.9%), respectively. From 1991 to 2019, trend analysis showed NAFLD increased from 21.9% to 37.3% (yearly increase of 0.7%, P < .0001), with South America showing the most rapid change of 2.7% per year, followed by Europe at 1.1%.
Conclusions
Despite regional variation, the global prevalence of NAFLD is increasing overall. Policy makers must work toward reversing the current trends by increasing awareness of NAFLD and promoting healthy lifestyle environments.
中文翻译:
2019 年全球 NAFLD 患病率:系统回顾和荟萃分析
背景与目标
肥胖和 2 型糖尿病发病率的增加可能导致非酒精性脂肪性肝病 (NAFLD) 的患病率增加。我们旨在确定 NAFLD 全球和区域流行的当前和近期趋势。
方法
从开始到 2020 年 3 月 26 日的系统搜索是在没有语言限制的情况下进行的。两位作者独立进行筛选和数据提取。我们进行了荟萃回归以确定 NAFLD 患病率的趋势。
结果
我们从文献检索中确定了 17,244 篇文章,并纳入了 245 项符合条件的研究,涉及 5,399,254 人。NAFLD 的综合全球患病率为 29.8%(95% 置信区间 [CI],28.6%–31.1%);其中,82.5% 的纳入文章使用超声诊断 NAFLD,患病率为 30.6%(95% CI,29.2%–32.0%)。南美洲(3 项研究,5716 人)和北美(4 项研究,18236 人)的 NAFLD 患病率最高,分别为 35.7%(95% CI,34.0%–37.5%)和 35.3%(95% CI,25.4%–45.9) %), 分别。从 1991 年到 2019 年,趋势分析显示 NAFLD 从 21.9% 增加到 37.3%(每年增加 0.7%,P < .0001),其中南美洲每年变化最快,为 2.7%,其次是欧洲,为 1.1%。
结论
尽管存在地区差异,但 NAFLD 的全球患病率总体上呈上升趋势。政策制定者必须通过提高对 NAFLD 的认识和促进健康的生活方式环境来努力扭转当前的趋势。