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Advances in biomineralization-inspired materials for hard tissue repair
International Journal of Oral Science ( IF 14.9 ) Pub Date : 2021-12-07 , DOI: 10.1038/s41368-021-00147-z
Shuxian Tang 1 , Zhiyun Dong 1 , Xiang Ke 1 , Jun Luo 1 , Jianshu Li 1, 2
Affiliation  

Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties, including the bones and teeth in vertebrates. The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues. In particular, the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization. Here, we review recent advances in biomineralization-inspired materials developed for hard tissue repair. Biomineralization-inspired materials are categorized into different types based on their specific applications, which include bone repair, dentin remineralization, and enamel remineralization. Finally, the advantages and limitations of these materials are summarized, and several perspectives on future directions are discussed.



中文翻译:

用于硬组织修复的生物矿化启发材料的进展

生物矿化是生物体形成具有层次结构和优良特性的矿化组织的过程,包括脊椎动物的骨骼和牙齿。生物矿化的潜在机制和途径为设计和构建修复硬组织的材料提供了灵感。特别是,通过利用仿生人造材料模拟生物分子的功能或稳定参与生物矿化的中间矿物相,可以部分复制矿物的形成过程。在这里,我们回顾了为硬组织修复开发的受生物矿化启发的材料的最新进展。受生物矿化启发的材料根据其具体应用分为不同类型,包括骨修复、牙本质再矿化和牙釉质再矿化。

更新日期:2021-12-07
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