Iron overload (IO) is a frequent finding in the general population. As the major iron storage site, the liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. We aimed to determine whether FXR plays a role in regulating iron hepatotoxicity.

中文翻译：

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小鼠和人类铁过载抑制法尼醇 X 受体增强铁诱导的肝毒性

铁超负荷 (IO) 在普通人群中很常见。作为主要的铁储存场所，肝脏受到铁毒性的影响。法尼醇 X 受体 (FXR) 调节胆汁酸代谢并与各种肝病有关。我们旨在确定 FXR 是否在调节铁肝毒性中发挥作用。