The base-induced formal [4+3] annulation reaction of in situ-formed aza-o-quinone methides and pyridinium 1,4-zwitterionic thiolates is reported. This protocol provides a novel and reliable method for the synthesis of biologically interesting benzo[e][1,4]thiazepine derivatives in synthetically useful yields. In addition, postsynthetic modification results in the formation of its sulfoxide and sulfone derivatives.

中文翻译：

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氮杂邻醌甲基化物与吡啶鎓1,4-两性硫醇盐的碱诱导形式[4+3]环化反应合成苯并[e][1,4]硫氮杂

报道了原位形成的氮杂-邻-醌甲基化物和吡啶鎓1,4-两性离子硫醇盐的碱诱导形式[4+3]环化反应。该协议提供了一种新颖且可靠的方法，用于以合成有用的产量合成具有生物学意义的苯并[ e ][1,4]硫氮杂衍生物。此外，合成后修饰导致其亚砜和砜衍生物的形成。