Based on an one-step acid-base neutralization method, several biocompatible anions-derived ionic liquids (bio-AILs) were prepared and characterized. They were first used as dual solvent-catalyst for cyclization of CO₂ and 2-aminobenzonitriles to synthesize quinazoline-2,4(1H,3H)-diones. The influence of different bio-AILs structures on the cyclization reaction were studied, and [HTMG][Lae] was confirmed to be an excellent medium. By optimizing the reaction conditions, the [HTMG][Lae]-mediated cyclization reaction could afford a 96 % quinazoline-2,4(1H,3H)-dione yield at 70 °C, 1.0 MPa CO₂ pressure for 6 h without other additives. The catalytic activities of various homogeneous media for transformation of CO₂ into quinazoline-2,4(1H,3H)-dione were analyzed and compared. In addition, the reusability and general applicability of the [HTMG][Lae] medium were examined, the [HTMG][Lae] could show comparable activity in the fifth experiment, and it had good versatility for cyclization of CO₂ with various 2-aminobenzonitriles. Finally, an insight into the activation behaviors of [HTMG][Lae] to reactants were further investigated, and based on this, a feasible reaction mechanism was proposed.

基于一步酸碱中和方法，制备并表征了几种生物相容性阴离子衍生的离子液体（bio-AILs）。它们首先被用作双溶剂催化剂，用于 CO ₂和 2-氨基苯甲腈的环化以合成喹唑啉-2,4(1 H ,3 H )-二酮。研究了不同生物 AILs 结构对环化反应的影响，并证实 [HTMG][Lae] 是一种极好的培养基。通过优化反应条件，[HTMG][Lae]介导的环化反应可以在70°C、1.0 MPa CO ₂条件下提供96%的喹唑啉-2,4(1 H ,3 H )-二酮收率在没有其他添加剂的情况下加压 6 小时。分析和比较了各种均相介质对CO ₂转化为喹唑啉-2,4(1 H ,3 H )-二酮的催化活性。此外，考察了[HTMG][Lae]介质的可重​​复使用性和普遍适用性，[HTMG][Lae]在第五次实验中表现出相当的活性，并且对于CO ₂与各种2-的环化具有良好的通用性。氨基苯甲腈。最后，进一步研究了[HTMG][Lae]对反应物的活化行为，并在此基础上提出了可行的反应机理。