Purpose

The pathology of Parkinson's disease (PD) is suspected to affect the retina and choroid. We investigated changes in the retina and choroid of patients with PD using optical coherence tomography.

Methods

We examined 14 patients with PD and 22 patients without PD. Patients without PD had no ophthalmic disease other than cataracts. In addition, it was also confirmed that there was no neurodegenerative disease. The retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and choroidal thickness were compared between both groups. Additionally, the choroidal image was divided into the choroid area, luminal area, and interstitial area using the binarization method, and the area of each region and the percentage of luminal area in the choroid area were analyzed.

Results

Patients with PD had a significantly thinner ganglion cell layer + inner plexiform layer compared to those without PD. The choroid area, luminal area, and interstitial area were significantly decreased in patients with PD compared to those without PD. Seven patients with PD who were successfully followed up showed decreased retinal nerve fiber layer and interstitial area after 3 years.

Conclusion

Autonomic nervous disorders and neurodegeneration in PD can cause thinning of the retina and choroid, as well as a reduction in the choroid area.

中文翻译：

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光学相干断层扫描对帕金森病视网膜和脉络膜病理生理学的研究

目的

帕金森病 (PD) 的病理学被怀疑影响视网膜和脉络膜。我们使用光学相干断层扫描研究了 PD 患者视网膜和脉络膜的变化。

方法

我们检查了 14 名 PD 患者和 22 名无 PD 患者。没有 PD 的患者除白内障外没有眼部疾病。此外，还确认没有神经退行性疾病。比较两组的视网膜神经纤维层、神经节细胞层+内丛状层、脉络膜厚度。此外，采用二值化方法将脉络膜图像分为脉络膜区域、管腔区域和间质区域，并分析每个区域的面积和管腔面积在脉络膜区域中的百分比。

结果

与没有 PD 的患者相比，PD 患者的神经节细胞层 + 内丛状层明显更薄。与非PD患者相比，PD患者的脉络膜面积、管腔面积和间质面积显着减少。7 例成功随访的 PD 患者 3 年后视网膜神经纤维层和间质面积减少。

结论

PD 中的自主神经障碍和神经变性可导致视网膜和脉络膜变薄，以及脉络膜面积减少。