Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy,Hepatology

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Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy
Hepatology ( IF 13.5 ) Pub Date : 2021-12-02 , DOI: 10.1002/hep.32256
Hironari Kawai _{1,

2} , Yosuke Osawa _{1,

3} , Michitaka Matsuda ₁ , Tomoyuki Tsunoda ₄ , Keisuke Yanagida ₅ , Daisuke Hishikawa ₅ , Miku Okawara ₁ , Yuzuru Sakamoto ₁ , Tomonari Shimagaki ₁ , Yuriko Tsutsui ₁ , Yuichi Yoshida ₁ , Shiori Yoshikawa ₁ , Kana Hashi ₁ , Hiroyoshi Doi ₁ , Taizo Mori ₁ , Taiji Yamazoe ₁ , Sachiyo Yoshio ₁ , Masaya Sugiyama ₆ , Daisuke Okuzaki ₇ , Haruki Komatsu ₈ , Ayano Inui ₄ , Miwa Tamura-Nakano ₉ , Chinatsu Oyama ₉ , Hideo Shindou _{5,

10} , Hironori Kusano ₁₁ , Masayoshi Kage ₁₂ , Toru Ikegami ₂ , Katsuhiko Yanaga ₂ , Tatsuya Kanto ₁

Affiliation

The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan.
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Department of Gastroenterology, International University of Health and Welfare Hospital, Nasushiobara, Tochigi, Japan.
Department of Pediatric Hepatology and Gastroenterology, Saiseikai Yokohama-shi Tobu Hospital, Kanagawa, Japan.
Department of Lipid Signaling, National Center for Global Health and Medicine, Tokyo, Japan.
Genome Medical Sciences Project, National Center for Global Health and Medicine, Chiba, Japan.
Genome information Research Center, Research Institute for Microbial Disease, Osaka University, Suita, Osaka, Japan.
Department of Pediatrics, Toho University Medical Center, Sakura hospital, Chiba, Japan.
Communal Laboratory, National Center for Global Health and Medicine, Tokyo, Japan.
Department of Lipid Science, The University of Tokyo, Tokyo, Japan.
Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
Kurume University Research Center for Innovative Cancer Therapy, Fukuoka, Japan.

Chronic liver congestion reflecting right-sided heart failure (RHF), Budd-Chiari syndrome, or Fontan-associated liver disease (FALD) is involved in liver fibrosis and HCC. However, molecular mechanisms of fibrosis and HCC in chronic liver congestion remain poorly understood.

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