Poor and asymmetric fetal growth have been associated with neonatal brain injury (BI) and worse neurodevelopmental outcomes (NDO) in the growth-restricted population due to placental insufficiency. We tested the hypothesis that postnatal markers of fetal growth (birthweight (BW), head circumference (HC), and head to body symmetry) are associated with preoperative white matter injury (WMI) and NDO in infants with single ventricle physiology (SVP) and d-transposition of great arteries (TGA). 173 term newborns (106 TGA; 67 SVP) at two sites had pre-operative brain MRI to assess for WMI and measures of microstructural brain development. NDO was assessed at 30 months with the Bayley Scale of Infant Development-II (n = 69). We tested the association between growth parameters at birth with the primary outcome of WMI on the pre-operative brain MRI. Secondary outcomes included measures of NDO. Newborns with TGA were more likely to have growth asymmetry with smaller heads relative to weight while SVP newborns were symmetrically small. There was no association between BW, HC or asymmetry and WMI on preoperative brain MRI or with measures of microstructural brain development. Similarly, growth parameters at birth were not associated with NDO at 30 months. In a multivariable model only cardiac lesion and site were associated with NDO. Unlike other high-risk infant populations, postnatal markers of fetal growth including head to body asymmetry that is common in TGA is not associated with brain injury or NDO. Lesion type appears to play a more important role in NDO in CHD.

胎儿生长不良和不对称与新生儿脑损伤（BI）以及胎盘功能不全导致生长受限人群的神经发育结局（NDO）较差有关。我们测试了这样的假设：胎儿生长的产后标志物（出生体重（BW）、头围（HC）和头体对称性）与单心室生理学（SVP）婴儿的术前白质损伤（WMI）和 NDO 相关，并且d-大动脉转位（TGA）。对两个地点的 173 名足月新生儿（106 名 TGA；67 名 SVP）进行了术前脑 MRI 评估，以评估 WMI 和大脑微结构发育的测量。NDO 在 30 个月时使用贝利婴儿发育量表 II 进行评估（n  = 69）。我们通过术前脑 MRI 测试了出生时生长参数与 WMI 主要结局之间的关联。次要结果包括 NDO 的测量。患有 TGA 的新生儿更有可能出现生长不对称，头部相对于体重较小，而 SVP 新生儿则对称地较小。术前脑 MRI 或脑微结构发育测量结果显示，BW、HC 或不对称性与 WMI 之间没有关联。同样，出生时的生长参数与 30 个月时的 NDO 无关。在多变量模型中，仅心脏病变和部位与 NDO 相关。与其他高危婴儿人群不同，胎儿生长的产后标志物（包括 TGA 中常见的头身体不对称）与脑损伤或 NDO 无关。病变类型似乎在 CHD 的 NDO 中发挥更重要的作用。