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The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients
Frontiers in Cardiovascular Medicine ( IF 3.6 ) Pub Date : 2021-12-02 , DOI: 10.3389/fcvm.2021.763389
Philip W Connelly 1, 2, 3 , Andrew T Yan 4 , Michelle M Nash 5 , Rachel M Wald 6 , Charmaine Lok 7 , Lakshman Gunaratnam 8 , Anish Kirpalani 9 , G V Ramesh Prasad 5
Affiliation  

Background: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole. We previously reported that the decrease in NT-proB-type natriuretic peptide (NT-proBNP) was associated with a decrease in adiponectin. Paraoxonase 1 (PON1) has been inversely associated with cardiovascular outcomes. We now report the association of changes in PON1 with changes in left ventricular volume and left ventricular mass after kidney transplantation.

Design: Patients on dialysis were assessed at baseline and 12 months after kidney transplantation (n = 38). A comparison group of patients on dialysis who were not expected to receive a transplant in the next 24 months were studied (n = 43) to determine if the change of PON1 with kidney transplantation achieved a significance greater than that due to biologic variation. Left ventricular volume and mass were determined by cardiac magnetic resonance imaging. PON1 was measured by arylesterase activity and by mass.

Results: PON1 mass and activity were not different between the groups at baseline. Both PON1 mass and activity were increased post-kidney transplantation (p < 0.0001 for change). The change in PON1 mass (p = 0.0062) and PON1 arylesterase activity (p = 0.0254) were inversely correlated with the change in NT-proBNP for patients receiving a kidney transplant. However, only the change in the PON1 mass, and not the change in PON1 arylesterase, was inversely correlated with the change in left ventricular volume (ml/m2.7) (p = 0.0146 and 0.0114 for diastolic and systolic, respectively) and with the change in hemoglobin (p = 0.0042).

Conclusion: Both PON1 mass and arylesterase activity are increased by kidney transplantation. The increase in PON1 mass is consistent with a novel relationship to the increase in hemoglobin and decrease in left ventricular volume and NT-proBNP seen when kidney function is restored.



中文翻译:

对氧磷酶 1 的增加与肾移植受者左心室容积的减少有关

背景:透析患者的心脏功能受损,部分原因是液体容量和心室压力增加。通过移植恢复的肾功能减少了收缩期和舒张期的左心室容积。我们之前报道过 NT-proB 型利钠肽 (NT-proBNP) 的减少与脂联素的减少有关。对氧磷酶 1 (PON1) 与心血管结局呈负相关。我们现在报告 PON1 的变化与肾移植后左心室容积和左心室质量变化的关联。

设计: 透析患者在基线和肾移植后 12 个月进行评估(n= 38)。对预计在未来 24 个月内不会接受移植的透析患者进行了研究。n= 43) 以确定肾移植后 PON1 的变化是否比生物变异引起的显着性更大。左心室体积和质量由心脏磁共振成像确定。PON1 是通过芳基酯酶活性和质量来测量的。

结果:基线时各组之间的 PON1 质量和活性没有差异。肾移植后 PON1 的质量和活性均增加(p< 0.0001 表示变化)。PON1质量的变化(p = 0.0062) 和 PON1 芳基酯酶活性 (p= 0.0254) 与接受肾移植的患者的 NT-proBNP 变化呈负相关。然而,只有 PON1 质量的变化,而不是 PON1 芳基酯酶的变化,与左心室容积的变化 (ml/m2.7) 呈负相关(p = 0.0146 和 0.0114 分别为舒张压和收缩压)以及血红蛋白的变化(p = 0.0042)。

结论:肾移植可增加 PON1 质量和芳基酯酶活性。PON1 质量的增加与肾功能恢复时血红蛋白增加、左心室容积和 NT-proBNP 减少的新关系一致。

更新日期:2021-12-02
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