Heart failure (HF) is the common consequences of various cardiovascular diseases, often leading to severe cardiac output deficits with a high morbidity and mortality. In recent years, light emitting diodes-based therapy (LEDT) has been widely used in multiple cardiac diseases, while its modulatory effects on cardiac function with HF still remain unclear. Therefore, the objective of this study was to investigate the effects of LED-Red irradiation on cardiac function in mice with HF and to reveal its mechanisms. In this study, we constructed a mouse model of HF. We found that LED-Red (630 nm) was an effective wavelength for the treatment of HF. Meanwhile, the application of LED-Red therapy to treat HF mice improved cardiac function, ameliorate heart morphology, reduced pulmonary edema, as well as inhibited collagen deposition. Moreover, LED-Red therapy attenuated the extent of perivascular fibrosis. Besides, LED-Red irradiation promoted calcium transients in cardiomyocytes as well as upregulated ATP synthesis, which may have positive implications for contractile function in mice with HF. Collectively, we identified that LED-Red exerts beneficial effects on cardiac function in HF mice possibly by promoting the synthesis of ATP.

心力衰竭 (HF) 是各种心血管疾病的常见后果，通常会导致严重的心输出量不足，具有很高的发病率和死亡率。近年来，基于发光二极管的治疗（LEDT）已广泛应用于多种心脏疾病，但其对心衰心功能的调节作用仍不清楚。因此，本研究的目的是研究 LED-Red 照射对 HF 小鼠心脏功能的影响并揭示其机制。在这项研究中，我们构建了一个 HF 小鼠模型。我们发现 LED-Red (630 nm) 是治疗 HF 的有效波长。同时，应用 LED-Red 疗法治疗 HF 小鼠可改善心脏功能，改善心脏形态，减少肺水肿，并抑制胶原蛋白沉积。而且，LED-Red 疗法减轻了血管周围纤维化的程度。此外，LED-Red 照射促进了心肌细胞中的钙瞬变以及上调 ATP 合成，这可能对 HF 小鼠的收缩功能产生积极影响。总的来说，我们发现 LED-Red 可能通过促进 ATP 的合成对 HF 小鼠的心脏功能产生有益影响。