Dissecting contributions of microglia to human brain development and disease pathogenesis requires modeling interactions between these microglia and their local environment. In this issue of Cell Stem Cell, Popova et al. (2021) propose a transcriptomic “microglia report card” and create a neuroimmune organoid to model complex interactions involving human microglia.

中文翻译：

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小胶质细胞调节人类神经免疫类器官的神经发育

剖析小胶质细胞对人类大脑发育和疾病发病机制的贡献需要模拟这些小胶质细胞与其局部环境之间的相互作用。在本期Cell Stem Cell 中，Popova 等人。(2021) 提出了转录组学“小胶质细胞报告卡”，并创建了一种神经免疫类器官来模拟涉及人类小胶质细胞的复杂相互作用。