Into the multiverse of gene edited NK cell-based therapeutic strategies,Cell Stem Cell

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Into the multiverse of gene edited NK cell-based therapeutic strategies
Cell Stem Cell ( IF 23.9 ) Pub Date : 2021-12-02 , DOI: 10.1016/j.stem.2021.11.004
Benjamin H Goldenson ₁ , Dan S Kaufman ₁

Affiliation

In this issue of Cell Stem Cell, Woan et al., (2021) investigate the anti-cancer activity of triple gene edited iPSC-derived natural killer (NK) cells and demonstrate that expression of a modified CD16a and interleukin (IL)-15 receptor combined with knockout of CD38 improves NK cell-mediated activity against leukemia and multiple myeloma.

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