OBJECTIVE To assess self-reported executive dysfunction in young adult patients with persistent post-concussion symptoms (PCS) 2-6 months post-injury, and the association with self-reported Health-Related Quality of Life (HRQoL). METHOD This cross-sectional study carried out in a hospital setting was a secondary analysis of data from a separate randomized trial testing the effect of a novel intervention, "Get going After concussIoN " (GAIN), for persistent PCS. Patients (18-30 years) were recruited from a clinical cohort of patients with a hospital diagnosis of concussion or referred by primary care physicians. Main measures were The Behaviour Rating Inventory of Executive Function-Adult Version providing two index scores, that is, the Metacognitive Index (MI) and the Behavioural Regulation Index (BRI), and the Quality of Life after Brain Injury-Overall Scale. RESULTS Compared with normative data, patients had elevated scores (i.e., worse functioning) on both the MI and the BRI. In linear regression analysis, the MI score, but not the BRI score, was negatively associated with self-reported HRQoL (MI: slope = -.27, 95% confidence interval, CI [-.53, -.02], p = .03; BRI: slope = -.19, 95% CI [-.49, .13], p = .24), suggesting a positive association of subjective executive dysfunction and lower HRQoL. However, the association was attenuated after adjustment for self-reported psychological distress (MI: slope = -.09, 95% CI [-.34, .17], p = .51). CONCLUSION Self-reported executive dysfunction is common in young adult patients with persistent PCS, but not strongly associated with decreased HRQoL after adjusting for concurrent psychological distress.

中文翻译：

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具有持续性脑震荡后症状的年轻人的自评执行功能和与健康相关的生活质量：一项横断面研究。

目的 评估受伤后 2-6 个月具有持续性脑震荡后症状 (PCS) 的年轻成年患者自我报告的执行功能障碍，以及与自我报告的健康相关生活质量 (HRQoL) 的关系。方法 这项在医院环境中进行的横断面研究是对来自另一项随机试验的数据的二次分析，该试验测试了一种新型干预措施“脑震荡后继续”(GAIN) 对持续性 PCS 的影响。患者（18-30 岁）是从医院诊断为脑震荡或由初级保健医生转诊的患者临床队列中招募的。主要测量指标为执行功能行为评定量表-成人版，提供两个指数分数，即元认知指数（MI）和行为调节指数（BRI），和脑损伤后的生活质量-总体量表。结果 与标准数据相比，患者的 MI 和 BRI 评分均有所提高（即功能更差）。在线性回归分析中，MI 评分而非 BRI 评分与自我报告的 HRQoL 呈负相关（MI：斜率 = -.27，95% 置信区间，CI [-.53，-.02]，p = .03；BRI：斜率 = -.19, 95% CI [-.49, .13], p = .24)，表明主观执行功能障碍与较低的 HRQoL 呈正相关。然而，在对自我报告的心理困扰进行调整后，这种关联减弱了（MI：斜率 = -.09, 95% CI [-.34, .17], p = .51）。结论 自我报告的执行功能障碍在患有持续性 PCS 的年轻成年患者中很常见，但在调整并发的心理困扰后与 HRQoL 下降没有密切相关。