Since the oral cavity is a harsh environment where various germs and chemical and mechanical stress exist simultaneously, well-organized hybrid technology should be considered in the design of cutting-edge dental materials. Although the Clear Overlay Appliance (COA) is widely used as a transparent orthodontic device, it still requires specific modifications to overcome the poor durability and frequent contamination that cause the patient's therapeutic burden. Herein, robust polysilsesquioxane (PSQ) containing quaternary ammonium cations (QACs) and long alkyl chains (LACs) in a durable siloxane matrix are reported as coating materials for the advanced COAs. The PSQ coatings are engineered to have a ladder-like structure that exhibits excellent stability under various pH and enzymatic conditions. Experiments simulating the dynamic intraoral are established to investigate the effects of PSQ coatings for the functional improvement of COA. The QACs and LACs firmly fixed to the siloxane matrix cause bacterial contact killing to prevent the contamination of COAs in the environment exposed to bacteria. The ladder-like siloxane matrix of the coating protects the COAs from intraoral abrasion forces and shearing movements with its flexible adaptability to external stresses. This study clarifies the clinical application potential of the coated COAs via in-vivo experiments using the beagle model.

由于口腔是一个恶劣的环境，各种细菌和化学和机械应力同时存在，因此在设计尖端牙科材料时应考虑组织良好的混合技术。尽管透明覆盖装置 (COA) 被广泛用作透明的正畸装置，但它仍然需要进行特定的修改，以克服耐用性差和经常污染导致患者治疗负担的问题。在此，据报道在耐用的硅氧烷基质中含有季铵阳离子 (QAC) 和长烷基链 (LAC) 的坚固聚倍半硅氧烷 (PSQ) 作为高级 COA 的涂层材料。PSQ 涂层设计为具有阶梯状结构，在各种 pH 值和酶促条件下表现出出色的稳定性。建立了模拟口腔内动态的实验，以研究 PSQ 涂层对 COA 功能改善的影响。牢固固定在硅氧烷基质上的 QAC 和 LAC 会导致细菌接触杀灭，以防止暴露于细菌的环境中的 COA 污染。涂层的阶梯状硅氧烷基质以其对外部应力的灵活适应性保护 COA 免受口腔内磨损力和剪切运动的影响。本研究通过使用比格犬模型的体内实验阐明了涂层 COA 的临床应用潜力。涂层的阶梯状硅氧烷基质以其对外部应力的灵活适应性保护 COA 免受口腔内磨损力和剪切运动的影响。本研究通过使用比格犬模型的体内实验阐明了涂层 COA 的临床应用潜力。涂层的阶梯状硅氧烷基质以其对外部应力的灵活适应性保护 COA 免受口腔内磨损力和剪切运动的影响。本研究通过使用比格犬模型的体内实验阐明了涂层 COA 的临床应用潜力。