Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is the most significant feature of chemodynamic therapy (CDT). Owing to the mild acid and overexpressed H₂O₂ in TME, more cytotoxic hydroxyl radicals (˙OH) are generated in tumor cells via Fenton and Fenton-like reactions. Without external stimulus and drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific and desirable anticancer effect and has been seen as a promising strategy for cancer therapy. However, optimizing the treatment efficiency of CDT in TME is still challenging because of the limited catalytic efficiency of CDT agents and the strong cancer antioxidant capacity in TME. Hence, scientists are trying their best to design and fabricate many more CDT agents with excellent catalytic activity and remodeling TME for optimal CDT. In this perspective, the latest progress of CDT is discussed, with some representative examples presented. Consequently, promising strategies for further optimizing the efficiency of CDT guided by Fenton chemistry are provided. Most importantly, several feasible ways of developing CDT in the future are offered for reference.

中文翻译：

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基于芬顿/类芬顿化学的癌症化学动力学治疗的最新进展

将芬顿化学应用于肿瘤微环境（TME）进行癌症治疗是化学动力学疗法（CDT）最显着的特点。由于TME中的弱酸和过度表达的H ₂ O ₂ ，通过芬顿和类芬顿反应在肿瘤细胞中产生更多的细胞毒性羟基自由基(˙OH) 。在没有外部刺激和耐药性产生的情况下，活性氧（ROS）介导的CDT表现出特异且理想的抗癌效果，被视为一种有前途的癌症治疗策略。然而，由于CDT药物的催化效率有限以及TME中强大的癌症抗氧化能力，优化CDT在TME中的治疗效率仍然具有挑战性。因此，科学家们正在尽最大努力设计和制造更多具有优异催化活性的CDT试剂，并重塑TME以获得最佳的CDT。从这个角度讨论了CDT的最新进展，并给出了一些有代表性的例子。因此，为进一步优化 Fenton 化学引导的 CDT 效率提供了有前景的策略。最重要的是，为未来发展CDT提供了几种可行的途径可供参考。