Individuals with bulimia nervosa (BN) cycle between periods of binge-eating and compensatory behavior and periods of dietary restraint, suggesting extremes of under and overcontrol that may be metabolic-state related. This study examined the influence of hunger and satiety on impulsivity and neural responding during decision-making. Twenty-three women remitted from BN (RBN) and 20 healthy comparison women (CW) performed a delay discounting task after a 16-hr fast and following a standardized meal during functional neuroimaging. A dual-systems approach examined reward valuation (decision trials where the early reward option was available immediately) and cognitive control (all decision trials). Interactions of Group × Visit (Hungry, Fed) for immediate reward revealed that CW had greater activation when hungry versus fed in the ventral striatum and dorsal caudate, whereas RBN had greater response when fed versus hungry in the dorsal caudate. Compared to CW, RBN showed decreased response when hungry within the left dorsal caudate and ventral striatum and increased response when fed in bilateral dorsal caudate. No differences were found within cognitive control regions or with choice behavior. Reward sensitivity is normally increased when hungry and decreased when fed; our findings in CW provide further support of hunger-based reward sensitivity within the striatum. However, RBN showed no differences for hunger and satiety in the ventral striatum and greater activation in the dorsal caudate when fed compared to hungry. This suggests RBN may be less sensitive to reward when hungry but do not devalue reward when satiated, indicating altered metabolic modulation of self-regulatory control. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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饱腹感不会改变腹侧纹状体对神经性贪食症立即奖励的反应。

患有神经性贪食症 (BN) 的个体在暴食和补偿行为时期和饮食限制时期之间循环，这表明可能与代谢状态相关的极端控制不足和过度控制。本研究考察了饥饿和饱腹感对决策过程中的冲动和神经反应的影响。23 名从 BN (RBN) 出院的女性和 20 名健康对照女性 (CW) 在功能性神经成像期间禁食 16 小时并在标准化膳食后执行延迟折扣任务。双系统方法检查了奖励评估（早期奖励选项立即可用的决策试验）和认知控制（所有决策试验）。团体×参观互动（饿了，Fed) 的即时奖励显示，CW 在饥饿时比在腹侧纹状体和背尾状体中进食时具有更大的激活，而 RBN 在进食时比在背侧尾状体中饥饿时具有更大的反应。与 CW 相比，RBN 在左背尾状核和腹侧纹状体内饥饿时表现出降低的反应，而在双侧背尾状核内进食时反应增加。在认知控制区域或选择行为中没有发现差异。奖励敏感度通常在饥饿时增加，在进食时减少；我们在 CW 中的发现进一步支持了纹状体中基于饥饿的奖励敏感性。然而，与饥饿相比，RBN 在腹侧纹状体的饥饿和饱腹感方面没有差异，而在喂食时，背侧尾状核的激活程度更高。这表明 RBN 在饥饿时可能对奖励不太敏感，但在饱腹时不会贬低奖励，这表明自我调节控制的代谢调节发生了改变。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。