Prospection refers to the ability to mentally construct future events, which is closely related to motivation and anhedonia. The neural underpinning of impaired prospection in psychiatric populations remains unclear. We recruited 34 individuals with autistic traits (AT), 27 individuals with schizotypal traits (ST), 31 individuals with depressive symptoms (DS), and 35 controls. Participants completed a prospection task while undergoing functional Magnetic Resonance Imaging (MRI). We found that regions of the "default mode network" including the medial frontal gyrus, the posterior cingulate cortex, the precuneus and the parahippocampus were activated; and regions of the "task-positive network" including the inferior parietal lobe, the inferior frontal gyrus and the precentral gyrus were deactivated during prospection in controls. Compared with controls, AT, ST, and DS showed comparable behavioral performance on prospection. However, reduced activation in anterior cingulate cortex and frontal gyrus was found in AT individuals relative to controls during prospection. ST individuals showed hyperactivation in the caudate relative to controls when processing positive emotion, while DS individuals and controls showed similar neural responses during prospection. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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具有分裂型特征、自闭症特征或抑郁症状的个体的神经机制。

展望是指在心理上构建未来事件的能力，与动机和快感缺乏密切相关。精神病人群中受损前景的神经基础仍不清楚。我们招募了 34 名具有自闭症特征 (AT) 的个体、27 名具有分裂型特征 (ST) 的个体、31 名具有抑郁症状 (DS) 的个体和 35 名对照者。参与者在接受功能性磁共振成像 (MRI) 的同时完成了一项勘探任务。我们发现“默认模式网络”的区域包括内侧额回、后扣带回皮层、楔前叶和海马旁回被激活；和“任务积极网络”的区域，包括顶下叶、额下回和中央前回，在对照的观察过程中被停用。与对照相比，AT、ST 和 DS 在前景方面表现出相当的行为表现。然而，在预期期间，相对于对照，在 AT 个体中发现前扣带回皮层和额回的激活减少。ST 个体在处理积极情绪时表现出相对于对照的尾状核过度激活，而 DS 个体和对照在展望过程中表现出相似的神经反应。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。而 DS 个体和对照在勘探过程中表现出相似的神经反应。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。而 DS 个体和对照在勘探过程中表现出相似的神经反应。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。