Fluorine-containing moieties are widely used in the pharmaceutical, agrochemical, and material fields. Thus, these structures are of immense interest in the fields of organic synthesis and medicinal chemistry. Among various fluorinated groups, the difluoromethyl unit has drawn increasing attention due to its unique pharmaceutical properties. In recent years, several methods for the synthesis of difluoromethylated compounds have been rapidly developed. However, most of these methods treat aromatic compounds with excess difluoromethylating reagents, which often contain organometallic compounds, so these transformations are generally less environmentally friendly and atom-economical. In this review, we summarize the recent development of new methods for the synthesis of difluoromethyl motifs or difluoroalkenes from trifluoromethylated aromatic compounds or trifluoromethyl alkenes via single C(sp³)−F bond cleavage.

中文翻译：

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三氟甲基合成二氟化结构的最新进展

含氟部分广泛应用于医药、农化和材料领域。因此，这些结构在有机合成和药物化学领域具有极大的兴趣。在各种含氟基团中，二氟甲基单元因其独特的药学性质而受到越来越多的关注。近年来，几种二氟甲基化化合物的合成方法得到了快速发展。然而，这些方法中的大多数使用过量的二氟甲基化试剂处理芳香族化合物，这些试剂通常含有有机金属化合物，因此这些转化通常不太环保和原子经济。在本次审查中，sp ³ )-F 键断裂。