Little is known about multiple medicines and initial therapy among people with dementia. To examine the effect of multiple medicines on the initiation of anti-dementia therapy in patients diagnosed with cognitive impairment (CI), a retrospective study with 2742 CI patients was conducted based on the outpatients’ medical records. The dementias receiving 1–2 drugs were more likely to be prescribed with anti-dementia (one drug: OR = 1.877; two drugs: OR = 1.770) and psychotropic (one drug: OR = 1.980) treatment, whereas had lower chances of receiving psychotropic medication with the combinations of more than three drugs (Alzheimer’s disease: OR = .365; vascular dementia: OR = .940; frontotemporal lobe degeneration: OR = .957; and dementia with Lewy bodies/Parkinson’s disease dementia: OR = .952). Multiple medicines can affect anti-dementia therapy initiation in dementia patients and should be paid extreme caution.

对于痴呆症患者的多种药物和初始治疗知之甚少。为了检查多种药物对诊断为认知障碍 (CI) 患者启动抗痴呆治疗的影响，根据门诊病历对 2742 名 CI 患者进行了一项回顾性研究。接受 1-2 种药物的痴呆患者更有可能接受抗痴呆（一种药物：OR = 1.877；两种药物：OR = 1.770）和精神药物（一种药物：OR = 1.980）治疗，而接受治疗的机会较低精神药物与三种以上药物的组合（阿尔茨海默病：OR = .365；血管性痴呆：OR = .940；额颞叶变性：OR = .957；路易体痴呆/帕金森病痴呆：OR = .952 ).