PURPOSE To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography. METHODS Foveal avascular zone (FAZ) of superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups. RESULTS The deep FAZ was significantly smaller in the eyes with AU during the attack than after recovery and the control group (p = 0.001 and p = 0.003, respectively). The VD in deep capillary plexus (DCP) in eyes with AU during the attack was significantly higher than the control group (p = 0.048). The VD in the foveal sector of DCP in eyes with AU during the attack and after recovery was significantly higher than the control group (p = 0.001 and p = 0.031, respectively). There was no significant difference regarding CMT, CFT, VDs of each segment and each sector, and superficial and deep FAZ between eyes with first uveitis attack and those with recurrent uveitis during the attack and after recovery (p > 0.05). CONCLUSION The results of this study show that there is a reduction in the FAZ and an increase in the VD of the DCP of the retina during active AU, and these findings are reversible. Acute AU may affect the macular microvasculature, which is usually temporary, especially in the DCP.

中文翻译：

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急性前葡萄膜炎的视网膜光学相干断层扫描血管造影结果。

目的 使用光学相干断层扫描血管造影评估前葡萄膜炎 (AU) 眼视网膜微血管的变化。方法：浅表毛细血管丛（SCP）和深部毛细血管丛（DCP）的中心凹无血管区（FAZ），SCP、DCP和脉络膜毛细血管的血管密度（VD），以及中央黄斑厚度（CMT）和中央凹厚度（CFT）。由 34 只健康的眼睛和 41 只葡萄膜炎的眼睛计算得出。比较两组的参数。结果 发作期间 AU 眼的深部 FAZ 明显小于恢复后和对照组（分别为 p = 0.001 和 p = 0.003）。发作期间 AU 眼深部毛细血管丛 (DCP) 的 VD 显着高于对照组 (p = 0.048)。AU 眼在发作期间和恢复后的 DCP 中央凹区 VD 显着高于对照组（分别为 p = 0.001 和 p = 0.031）。葡萄膜炎首发与葡萄膜炎复发时及恢复后各节段、各扇区的CMT、CFT、VD、浅表及深部FAZ差异均无统计学意义（p > 0.05）。结论 本研究结果表明，在活动性 AU 期间，视网膜 DCP 的 FAZ 减少和 VD 增加，并且这些发现是可逆的。急性 AU 可能会影响黄斑微血管系统，这通常是暂时的，尤其是在 DCP 中。葡萄膜炎首发与葡萄膜炎复发时及恢复后各节段、各扇区的CFT、VD、浅表和深部FAZ（p > 0.05）。结论 本研究结果表明，在活动性 AU 期间，视网膜 DCP 的 FAZ 减少和 VD 增加，并且这些发现是可逆的。急性 AU 可能会影响黄斑微血管系统，这通常是暂时的，尤其是在 DCP 中。葡萄膜炎首发与葡萄膜炎复发时及恢复后各节段、各扇区的CFT、VD、浅表和深部FAZ（p > 0.05）。结论 本研究结果表明，在活动性 AU 期间，视网膜 DCP 的 FAZ 减少和 VD 增加，并且这些发现是可逆的。急性 AU 可能会影响黄斑微血管系统，这通常是暂时的，尤其是在 DCP 中。