Ethambutol use may lead to permanent vision loss by inducing a dose- and duration-dependent optic neuropathy. This has been of concern to ophthalmologists and physicians both; however, ethambutol continues to be used because of its anti-mycobacterial action with relative systemic safety. Recently, the guidelines of the Revised National Tuberculosis Control Programme of India have been revised to allow for fixed dose and longer duration of ethambutol use; this is likely to result in an increase in vision-threatening adverse effects. Taking cognizance of this, neuro-ophthalmologists, infectious disease specialists, and scientists met under the aegis of the Indian Neuro-Ophthalmology Society to deliberate on prevention, early diagnosis, and management of ethambutol-related toxic optic neuropathy. The recommendations made by the expert group focus on early suspicion of ethambutol toxicity through screening at the physician's office and opportunistic screening by the ophthalmologist. Further, they focus on an early diagnosis through identification of specific clinical biomarkers and on management in way of early stoppage of the drug and supportive therapy. This statement also describes the mechanism of reporting a case of toxic optic neuropathy through the Pharmacovigilance Programme of India and emphasizes the need for spreading awareness regarding vision-threatening adverse effects among patients and healthcare workers.

中文翻译：

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乙胺丁醇毒性：乙胺丁醇引起的视神经病变的一级预防、诊断和管理专家小组共识。

乙胺丁醇的使用可能通过诱导剂量和持续时间依赖性视神经病变而导致永久性视力丧失。这一直是眼科医生和医生都关心的问题。然而，乙胺丁醇继续使用，因为它具有抗分枝杆菌作用，具有相对的全身安全性。最近，印度修订的国家结核病控制计划的指南进行了修订，以允许使用固定剂量和更长的乙胺丁醇使用时间；这可能会导致威胁视力的不良反应增加。考虑到这一点，神经眼科医生、传染病专家和科学家在印度神经眼科学会的主持下会面，讨论乙胺丁醇相关毒性视神经病变的预防、早期诊断和管理。专家组提出的建议侧重于通过在医生办公室进行筛查和眼科医生进行机会性筛查来早期怀疑乙胺丁醇毒性。此外，他们专注于通过识别特定的临床生物标志物进行早期诊断，并通过早期停止药物和支持治疗的方式进行管理。该声明还描述了通过印度药物警戒计划报告中毒性视神经病变病例的机制，并强调需要在患者和医护人员中传播有关威胁视力的不良反应的意识。他们专注于通过识别特定的临床生物标志物进行早期诊断，以及通过早期停药和支持治疗的方式进行管理。该声明还描述了通过印度药物警戒计划报告中毒性视神经病变病例的机制，并强调需要在患者和医护人员中传播有关威胁视力的不良反应的意识。他们专注于通过识别特定的临床生物标志物进行早期诊断，以及通过早期停药和支持治疗的方式进行管理。该声明还描述了通过印度药物警戒计划报告中毒性视神经病变病例的机制，并强调需要在患者和医护人员中传播有关威胁视力的不良反应的意识。