当前位置: X-MOL 学术Oxidative Med. Cell. Longev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1
Oxidative Medicine and Cellular Longevity ( IF 7.310 ) Pub Date : 2021-11-27 , DOI: 10.1155/2021/2231680
Jing Zhang 1 , Yiyang Hong 1 , Zhenyu Liuyang 2 , Haozhe Li 1 , Zhongyang Jiang 2 , Jingjing Tao 1 , Hai Liu 3 , Anyong Xie 2, 4 , Yili Feng 2 , Xingjian Dong 5 , Yihong Wang 6 , Qinghua Dong 1, 7 , Guanyu Wang 2
Affiliation  

Radiation-induced oral mucositis is a major adverse event of radiotherapy. Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long-term survival in cancer patients receiving radiotherapy, but until now, there have been no effective options for preventing radiation-induced oral mucositis. Quercetin is a flavonoid that is widely found in food species and has anti-inflammatory, antioxidant, and anticancer activities. In this study, we investigated a new role of quercetin in preventing radiation-induced oral mucositis. Quercetin exerted preventive effects against radiation-induced oral mucositis induced by single-dose (25 Gy) ionizing radiation or fractionated ionizing radiation () in C57BL/6 mice and maintained the proliferation ability of basal epithelial cells. Quercetin pretreatment alleviated reactive oxygen species generation, NF-κB pathway activation, and downstream proinflammatory cytokine production and reduced DNA double-strand breaks and cellular senescence induced by ionizing radiation. Quercetin also upregulated BMI-1 expression in oral epithelial cells and promoted ulcer repair. In addition, quercetin exerted similar radioprotective effects in irradiated primary cultured normal human keratinocytes, reduced reactive oxygen species generation and proinflammatory cytokine release, and promoted DNA double-strand break repair and wound healing by upregulating the expression of BMI-1, which is a polycomb group protein. Thus, quercetin can block multiple pathological processes of radiation-induced oral mucositis by targeting BMI-1 and may be a potential treatment option for preventing radiation-induced oral mucositis.

中文翻译:

槲皮素通过上调 BMI-1 预防辐射诱发的口腔粘膜炎

放射性口腔黏膜炎是放射治疗的主要不良事件。严重的口腔黏膜炎可能会导致放疗中断,并降低接受放疗的癌症患者的长期生存率,但直到现在,还没有有效的选择来预防辐射诱发的口腔黏膜炎。槲皮素是一种黄酮类化合物,广泛存在于食物中,具有抗炎、抗氧化和抗癌活性。在这项研究中,我们研究了槲皮素在预防辐射引起的口腔粘膜炎中的新作用。槲皮素对单剂量(25 Gy)电离辐射或分次电离辐射引起的放射性口腔粘膜炎具有预防作用。)在 C57BL/6 小鼠中并维持基底上皮细胞的增殖能力。槲皮素预处理减轻了活性氧的产生,NF- κB 通路激活,下游促炎细胞因子产生,减少电离辐射诱导的 DNA 双链断裂和细胞衰老。槲皮素还上调口腔上皮细胞中 BMI-1 的表达并促进溃疡修复。此外,槲皮素对经辐照的原代培养的正常人角质形成细胞具有相似的放射保护作用,减少活性氧的产生和促炎细胞因子的释放,并通过上调多梳 BMI-1 的表达促进 DNA 双链断裂修复和伤口愈合。组蛋白。因此,槲皮素可以通过靶向 BMI-1 来阻断放射性口腔黏膜炎的多种病理过程,可能是预防放射性口腔黏膜炎的潜在治疗选择。
更新日期:2021-11-27
down
wechat
bug