Background Genome-wide association studies have discovered hundreds of common genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of susceptibility loci into biological mechanisms and targets for drug discovery remains challenging. Intersecting genetic and gene expression data has led to the identification of candidate genes. However, previously studied tissues are often non-diseased and heterogeneous in cell composition, hindering accurate candidate prioritization. Therefore, we analyzed single-cell transcriptomics from atherosclerotic plaques for cell-type-specific expression to identify atherosclerosis-associated candidate gene-cell pairs.

中文翻译：

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交叉单细胞转录组学和全基因组关联研究确定了动脉粥样硬化的关键细胞群和候选基因

背景全基因组关联研究已经发现了数百种动脉粥样硬化疾病和心血管危险因素的常见遗传变异。将敏感性基因座转化为药物发现的生物学机制和靶点仍然具有挑战性。交叉遗传和基因表达数据导致了候选基因的鉴定。然而，先前研究的组织通常是无病的且细胞组成异质，阻碍了准确的候选优先排序。因此，我们分析了来自动脉粥样硬化斑块的单细胞转录组学的细胞类型特异性表达，以确定与动脉粥样硬化相关的候选基因-细胞对。