The aim of this work was to evaluate the adsorption capacity and mechanism of two antiviral drugs AVDs (lopinavir (LOP) and ritonavir (RIT)) on three various sewage sludges (SSLs). The results showed that SSLs differed in the structure and chemical composition and LOP and RIT had a high affinity to the studied SSLs (K_d in ranges 2076–3449 L/kg). The adsorption capacities differed between SSLs and ranged 7.55–8.71 mg/g (RIT) and 8.10–8.64 mg/g (LOP). The Freundlich model provided a best fitting of adsorption isotherms of all AVDs-SSLs. The adsorption kinetics were best described by pseudo-second order kinetic model. The adsorption of LOP and RIT on SSLs was exothermic, spontaneous, and thermodynamically feasible. The sorption of LOP and RIT to SSLs was complex due to the diverse chemical composition of SSLs and the differences in the chemical structure of AVDs. Analysis of binary solution of both AVDs showed the competition effect between AVDs and a decrease in adsorption efficiency (3–17%) compared to single solutions. The amount of desorbed AVDs from all SSLs was low (less than 15%). The findings of the present work are significant in the prediction of fate and persistence of AVDs on SSLs in the context of their further transmission and possible environmental contamination.

这项工作的目的是评估两种抗病毒药物 AVD（洛匹那韦（LOP）和利托那韦（RIT））对三种不同污水污泥（SSL）的吸附能力和机制。结果表明，SSLs的结构和化学成分不同，LOP和RIT对所研究的SSLs具有较高的亲和力（K _d在 2076–3449 L/kg 范围内）。SSLs 之间的吸附能力不同，范围为 7.55-8.71 mg/g (RIT) 和 8.10-8.64 mg/g (LOP)。Freundlich 模型提供了所有 AVDs-SSL 的吸附等温线的最佳拟合。吸附动力学最好用准二级动力学模型来描述。LOP 和 RIT 在 SSLs 上的吸附是放热的、自发的和热力学可行的。由于 SSLs 的不同化学成分和 AVDs 化学结构的差异，LOP 和 RIT 对 SSLs 的吸附是复杂的。对两种 AVD 的二元溶液的分析表明，与单一溶液相比，AVD 之间存在竞争效应，吸附效率降低（3-17%）。从所有 SSL 中解吸的 AVD 的量都较低（低于 15%）。