Immune and tissue stem cells retain an epigenetic memory of inflammation that intensifies sensitivity to future encounters. We investigated whether and to what consequence stem cells possess and accumulate memories of diverse experiences. Monitoring a choreographed response to wounds, we found that as hair follicle stem cells leave their niche, migrate to repair damaged epidermis, and take up long-term foreign residence there, they accumulate long-lasting epigenetic memories of each experience, culminating in post-repair epigenetic adaptations that sustain the epidermal transcriptional program and surface barrier. Each memory is distinct, separable, and has its own physiological impact, collectively endowing these stem cells with heightened regenerative ability to heal wounds and broadening their tissue-regenerating tasks relative to their naïve counterparts.

中文翻译：

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干细胞通过积累不同的表观遗传记忆来增强效力并改变组织适应性

免疫和组织干细胞保留了炎症的表观遗传记忆，从而增强了对未来遭遇的敏感性。我们调查了干细胞是否拥有并积累了不同经历的记忆以及产生了什么后果。监测对伤口的精心设计的反应，我们发现随着毛囊干细胞离开它们的生态位，迁移以修复受损的表皮，并在那里长期居住在那里，它们积累了每次经历的长期表观遗传记忆，最终在后修复维持表皮转录程序和表面屏障的表观遗传适应。每段记忆都是不同的、可分离的，并有其自身的生理影响，