PURPOSE Ocular hypertension (OHT) is a clinical entity characterized by elevated intraocular pressure (IOP) without optic nerve damage. In the presence of other risk factors, OHT may progress to glaucoma. This study aimed to evaluate ocular blood flow (OBF) and choroidal thickness (CT), which may be markers and/or risk factors that could assess the progression of OHT to glaucoma. MATERIAL AND METHODS Age and gender matched 60 eyes of 32 patients with OHT and 61 eyes of 31 control patients were included for this study. All participants underwent a detailed ophthalmological examination including best-corrected visual acuity, IOP measurement with Goldmann applanation tonometry, gonioscopy, optic nerve evaluation with 78 D lens, and visual field test with Humphrey visual field analyzer. Retinal nerve fiber layer, ganglion cell complex, and central corneal thickness measurements were performed by optical coherence tomography (OCT). CT was measured with OCT in the fovea, 1.5 mm, 2 mm, 2.5 mm nasal and temporal to the fovea and from nasal and temporal to the optic disk. OBF data including peak systolic velocity (PSV), end-diastolic velocity (EDV), resistivity index (RI) and pulsatility index (PI) were measured with color Doppler imaging (CDI) from the ophthalmic artery (OA), central retinal artery (CRA), medial and lateral branches of short posterior ciliary arteries (MPCA, LPCA). Systolic (SBP) and diastolic arterial blood pressure were also noted. RESULTS CT measurement at each point in the OHT group compared to the control group were found to be significantly thinner (p = 0.001). There was a decrement in CT from the fovea to the nasal and temporal retina in both groups. In the OHT group, there was a significant decrease in PSV and EDV of OA, CRA, MPCA, and LPCA, and a significant increase in PI and RI of measured arteries. (EDV p = 0.036, PI p = 0.006, RI p = 0.006 for OA and p = 0.001 for other arteries and all OBF measurements). There was a negative correlation between CT and age, IOP and axial length (AL) in OHT group (r = - 0.529, p = 0.001; r = - 0.258, p = 0.047; r = - 0.345, p = 0.007, respectively, for fovea). But there was no statistically significant correlation between CT and other measurements in the control group, except age (r = - 0.860 p = 0.001 for fovea). CONCLUSION We found that OBF decrement and choroidal thinning in OHT group compared with controls. Interpretation both of CT measurements with OCT and OBF parameters with CDI and new imaging technologies may help to prevent and reduce the possible optic nerve damage.

中文翻译：

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高眼压症的眼部血流和脉络膜厚度。

目的 高眼压症 (OHT) 是一种临床实体，其特征是眼内压 (IOP) 升高而无视神经损伤。在存在其他危险因素的情况下，OHT 可能会发展为青光眼。本研究旨在评估眼部血流 (OBF) 和脉络膜厚度 (CT)，这可能是评估 OHT 进展为青光眼的标志物和/或危险因素。材料和方法 年龄和性别匹配的 32 名 OHT 患者的 60 只眼和 31 名对照患者的 61 只眼被纳入本研究。所有参与者都接受了详细的眼科检查，包括最佳矫正视力、使用 Goldmann 压平眼压计测量眼压、前房角镜检查、使用 78 D 镜片进行视神经评估以及使用 Humphrey 视野分析仪进行视野测试。视网膜神经纤维层、神经节细胞复合体、通过光学相干断层扫描（OCT）进行中央角膜厚度测量。CT用OCT在中央凹、1.5mm、2mm、2.5mm鼻和颞部到中央凹以及从鼻部和颞部到视盘进行测量。OBF 数据包括峰值收缩速度 (PSV)、舒张末期速度 (EDV)、电阻率指数 (RI) 和搏动指数 (PI)，采用来自眼动脉 (OA)、视网膜中央动脉的彩色多普勒成像 (CDI) 进行测量。 CRA）、睫状后短动脉的内侧和外侧分支（MPCA、LPCA）。还记录了收缩压 (SBP) 和舒张压。结果发现与对照组相比，OHT 组每个点的 CT 测量值明显更薄（p = 0.001）。两组中从中央凹到鼻部和颞部视网膜的 CT 均有所下降。OHT组OA、CRA、MPCA、LPCA的PSV和EDV显着降低，测得的动脉PI和RI显着升高。（对于 OA，EDV p = 0.036，PI p = 0.006，RI p = 0.006，对于其他动脉和所有 OBF 测量，p = 0.001）。OHT组CT与年龄、眼压和眼轴长度(AL)呈负相关(r = - 0.529, p = 0.001; r = - 0.258, p = 0.047; r = - 0.345, p = 0.007,对于中央凹）。但除年龄外，对照组的 CT 和其他测量值之间没有统计学上的显着相关性（对于中央凹，r = - 0.860 p = 0.001）。结论 我们发现与对照组相比，OHT 组的 OBF 减少和脉络膜变薄。