Glucose oxidation reaction (GOR) plays a significant role in glucose fuel cells anode and glucose sensors. Therefore, optimizing the GOR catalyst nanostructure is auxiliary to their efficient operation. In this study, we present a cascade-assembled strategy to prepare CuO nanobundles (CuO-NB) with high-density and homogenous grain boundaries (GBs). The essence of activity in GOR that depended on GBs are thoroughly investigated. The increased glucose diffusion coefficient of CuO-NB means that GBs has a faster glucose mass transfer, which is attributed to the terraces in GBs dislocation surface. Furthermore, the accumulation of electrons on GBs makes the glucose adsorption increased and the free energy of dehydrogenation step decreased, leading to a lower glucose oxidation barrier. Therefore, CuO-NB is appropriate for non-invasive glucose detection and glucose fuel cells. This study sheds new light on the GBs effect in GOR and paves the way for developing high-efficiency electrocatalysts.

葡萄糖氧化反应 (GOR) 在葡萄糖燃料电池阳极和葡萄糖传感器中起着重要作用。因此，优化 GOR 催化剂纳米结构有助于其高效运行。在这项研究中，我们提出了一种级联组装策略来制备具有高密度和均匀晶粒的 CuO 纳米束（CuO-NB） 边界（GB）。彻底调查了依赖于 GB 的 GOR 活动的本质。CuO-NB 增加的葡萄糖扩散系数意味着 GBs 具有更快的葡萄糖传质，这归因于 GBs 位错表面的阶地。此外，电子在GBs上的积累使葡萄糖吸附增加，脱氢步骤的自由能降低，导致葡萄糖氧化障碍降低。因此，CuO-NB适用于无创葡萄糖检测和葡萄糖燃料电池。该研究为 GOR 中的 GBs 效应提供了新的视角，并为开发高效电催化剂铺平了道路。