A novel Tb³⁺-functionalized covalent organic framework-based polymer mixed-matrix membrane (Tb³⁺@COF MMM) has been successfully fabricated by incorporating the highly stable Tb³⁺@PI-COF as filler into polyvinylidene fluoride (PVDF) solution. Compared with pure COF membrane, MMM exhibits its good flexibility, processability and high detection sensitivity. The obtained Tb³⁺@COF-MMM (M) can be employed as a highly sensitive sensing platform for the sequential detection of oxolinic acid (OA) and nitrobenzene (NB) based on a “off-on-off” process. M has performed its great selectivity, high sensitivity, and low detection limit for detecting OA with “turn-on” mechanism. Moreover, owing to the good chemical stability and anti-interference of M sensor, it is prospective to efficiently detect residues of OA in serum or river water. After the detection of M-15 toward OA, the obtained fluorescent M-15/OA exhibits the rapid quenching, facile manipulation, cycling utility and low detection limits for sensing NB solution and vapor. This work has proposed a typical case of developing flexible Ln³⁺-functionalized COF-based polymer mixed-matrix membrane as a highly sensitive sensing platform for detecting OA and NB, simultaneously revealed the applied potentiality of M for monitoring animal health and environmental pollution.

^{通过将高度稳定的 Tb 3+} @PI-COF 作为填料加入聚偏二氟乙烯 (PVDF) 溶液中，成功制备了一种新型 Tb ³⁺官能化共价有机骨架基聚合物混合基质膜 (Tb ³⁺ @COF MMM) . 与纯COF膜相比，MMM具有良好的柔韧性、可加工性和较高的检测灵敏度。所获得的Tb ³⁺ @COF-MMM (M)可以作为一个高灵敏度的传感平台，用于基于“off-on-off”过程的邻苯二甲酸（OA）和硝基苯（NB）的顺序检测。米在“开启”机制检测 OA 方面表现出高选择性、高灵敏度和低检出限。此外，由于M传感器良好的化学稳定性和抗干扰性，有望有效检测血清或河水中的OA残留。在检测M-15对 OA 后，获得的荧光M-15/OA表现出快速猝灭、易于操作、循环实用性和低检测限，用于检测 NB 溶液和蒸气。本工作提出了开发柔性Ln ^{3+的典型案例}-功能化的基于 COF 的聚合物混合基质膜作为检测 OA 和 NB 的高灵敏度传感平台，同时揭示了 M 在监测动物健康和环境污染方面的应用潜力。