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Fat on plastic: Metabolic consequences of an LDPE diet in the fat body of the greater wax moth larvae (Galleria mellonella)
Journal of Hazardous Materials ( IF 13.6 ) Pub Date : 2021-11-25 , DOI: 10.1016/j.jhazmat.2021.127862
Bryan J Cassone 1 , Harald C Grove 1 , Nicholas Kurchaba 1 , Paola Geronimo 1 , Christophe M R LeMoine 1
Affiliation  

The caterpillar larvae of the greater wax moth (Galleria mellonella) are avid plastivores, as when provided a diet of low-density polyethylene (LDPE) they actively feed on it. Recent work has highlighted the importance of their microbiome in the putative biodegradation of this plastic polymer, though the impact of plastic metabolism on the insect host is less clear. In the present study, we undertook an integrative approach spanning all levels of biological organization to explore the effects of a plastic diet on the metabolic physiology of this animal model of plastic biodegradation. We demonstrate that an LDPE diet is not sufficient to maintain optimal larval growth and survival. In addition, we confirm that plastic fed waxworms retain their fat body lipid stores in a manner proportional to their individual polyethylene consumption suggesting a direct effect of LDPE biodegradation. At the functional level, the oxidative capacity of the fat body of LDPE-fed larvae is maintained reflecting unaltered metabolic function of the tissue. Finally, metabolomic analyses confirmed fat body lipid stores maintenance in LDPE-fed worms, but uncovered various other nutritional deficiencies. Overall, this work unveils novel insights in the complex interplay between LDPE biodegradation and the metabolic physiology of this model plastivore.



中文翻译:

塑料上的脂肪:LDPE 饮食对大蜡螟幼虫(Galleria mellonella)脂肪体的代谢后果

大蜡蛾 ( Galleria mellonella ) 的毛虫幼虫) 是狂热的塑料动物,因为当提供低密度聚乙烯 (LDPE) 的饮食时,它们会积极地以它为食。最近的工作强调了它们的微生物组在这种塑料聚合物的假定生物降解中的重要性,尽管塑料代谢对昆虫宿主的影响尚不清楚。在本研究中,我们采取了一种跨越生物组织各个层次的综合方法来探索塑料饮食对这种塑料生物降解动物模型的代谢生理学的影响。我们证明 LDPE 饮食不足以维持最佳的幼虫生长和存活。此外,我们确认塑料喂养的蜡虫以与其个体聚乙烯消耗成正比的方式保留其脂肪体脂质储存,这表明 LDPE 生物降解的直接影响。在功能层面,维持低密度聚乙烯喂养幼虫脂肪体的氧化能力,反映组织的代谢功能未改变。最后,代谢组学分析证实了 LDPE 喂养的蠕虫的脂肪体脂质储存维持,但发现了各种其他营养缺乏。总体而言,这项工作揭示了 LDPE 生物降解与该模型塑食动物代谢生理学之间复杂相互作用的新见解。

更新日期:2021-12-04
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