The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin, and international normalized ratio (INR) levels were recorded on the 1st, 5th, and 10th days of hospitalization in order to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8±10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (13%), liver failure (21%), ARDS (85%), acute kidney injury (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension, diabetes mellitus, use of acetylsalicylic acid (ASA) or low molecular weight heparin (LMWH), hemoglobin, D-dimer, INR, and acute kidney injury were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications.

中文翻译：

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161 例 COVID-19 致命病例的临床特征和大出血预测因素：一项回顾性观察研究。

本研究的目的是调查 COVID-19 非幸存者的患者特征和实验室参数，并找出严重出血并发症的危险因素。对于这项回顾性研究，我们收集了 2020 年 3 月 20 日至 4 月 30 日期间在我们重症监护室死于 COVID-19 的患者的数据。D-二聚体、血小板计数、C 反应蛋白 (CRP)、肌钙蛋白, 并在住院第 1、5 和 10 天记录国际标准化比 (INR) 水平，以研究实验室参数变化与住院事件的可能相关性。共有 161 名 COVID-19 非幸存者患者被纳入研究。中位年龄为 69.8±10.9 岁，95 人（59%）为男性。肺部相关并发症是最常见的住院并发症。COVID-19患者出现院内并发症，如大出血（39%）、咯血（14%）、弥散性血管内凝血（13%）、肝功能衰竭（21%）、ARDS（85%）、急性肾损伤（ 40%）和心肌损伤（70%）。多元逻辑回归分析确定，年龄、高血压、糖尿病、乙酰水杨酸 (ASA) 或低分子肝素 (LMWH) 的使用、血红蛋白、D-二聚体、INR 和急性肾损伤是大出血的独立预测因素。我们的结果表明，很大一部分 COVID-19 非幸存者患有严重的出血并发症。多元逻辑回归分析确定，年龄、高血压、糖尿病、乙酰水杨酸 (ASA) 或低分子肝素 (LMWH) 的使用、血红蛋白、D-二聚体、INR 和急性肾损伤是大出血的独立预测因素。我们的结果表明，很大一部分 COVID-19 非幸存者患有严重的出血并发症。多元逻辑回归分析确定，年龄、高血压、糖尿病、乙酰水杨酸 (ASA) 或低分子肝素 (LMWH) 的使用、血红蛋白、D-二聚体、INR 和急性肾损伤是大出血的独立预测因素。我们的结果表明，很大一部分 COVID-19 非幸存者患有严重的出血并发症。