Objective: Especially for adult patients with anorexia nervosa (AN), treatment response is generally low to moderate. The present study aimed to evaluate the efficacy of cognitive remediation therapy (CRT) as adjunctive treatment for AN regarding clinical and cognitive outcomes. Method: In this randomized controlled superiority trial, 167 adult and adolescent (≥17 years) patients with AN were randomly allocated (1:1) to 10 weekly sessions of group therapy of either CRT (n = 82) or art therapy (ART; n = 85) as an adjunct to inpatient treatment-as-usual (TAU). Outcomes were assessed at baseline, end-of-treatment (10 weeks), and 6-month follow-up. Change in body mass index (BMI), eating disorder psychopathology, and health-related quality of life (QoL) from baseline to 6-month follow-up served as primary outcomes. Improvements in motivation to change and several indices of set-shifting and central coherence between baseline and end-of-treatment and between baseline and 6-month follow-up served as secondary outcomes. Analysis was by intention to treat. Results: Treatment groups did not differ regarding change in BMI, eating disorder psychopathology, and health-related QoL from baseline to 6-month follow-up. Likewise, groups neither differed regarding improvements in these outcomes between baseline and end-of-treatment nor in motivation to change, set-shifting, and central coherence at any time, except for greater short-term improvements in one measure of set-shifting in the CRT group. Conclusions: CRT as an adjunct to inpatient TAU for AN was not efficacious in improving clinical and cognitive outcomes. The results do not support routine employment of CRT in inpatient treatment for AN. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

---

神经性厌食症的认知矫正疗法——一项随机临床试验。

目的：特别是对于神经性厌食症 (AN) 的成年患者，治疗反应一般为低至中度。本研究旨在评估认知矫正疗法 (CRT) 作为 AN 辅助治疗的临床和认知结果的疗效。方法：在这项随机对照优势试验中，167 名成人和青少年（≥17 岁）AN 患者被随机分配 (1:1) 至 10 次每周一次的 CRT（n = 82）或艺术治疗（ART； n = 85) 作为住院照常治疗 (TAU) 的辅助手段。在基线、治疗结束（10 周）和 6 个月的随访时评估结果。从基线到 6 个月随访的体重指数 (BMI)、饮食失调精神病理学和健康相关生活质量 (QoL) 的变化是主要结果。改变动机的改善以及基线和治疗结束之间以及基线和 6 个月随访之间的设置转移和中心一致性的几个指标作为次要结果。分析是按意向治疗。结果：从基线到 6 个月的随访，治疗组在 BMI、饮食失调精神病理学和健康相关 QoL 方面的变化没有差异。同样，各组在基线和治疗结束之间在这些结果的改善方面也没有差异，也没有在任何时候改变的动机、设定转移和中心一致性，除了在一项设定转移的衡量指标上有更大的短期改善。 CRT 组。结论：CRT 作为 AN 住院 TAU 的辅助手段在改善临床和认知结果方面无效。结果不支持在 AN 住院治疗中常规使用 CRT。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。