Neurology ( IF 9.9 ) Pub Date : 2021-11-23 , DOI: 10.1212/wnl.0000000000012899 Josep Dalmau 1 , Mar Guasp 1 , Francesc Graus 1
We appreciate the interest in our research.1 According to Pollak and colleagues,2 criteria of possible autoimmune psychosis (AP) are fulfilled if a patient has abrupt onset psychotic symptoms with at least one of the following: the presence of a tumor, movement disorder (dyskinesias, catatonia), adverse response to antipsychotics, "severe or disproportionate" cognitive dysfunction, decreased level of consciousness, unexplained seizures, and significant autonomic dysfunction.2 Fulfilment of these criteria should lead to additional tests such as EEG, MRI, and serum or CSF investigations. In our series of 105 patients with first episode of psychosis (FEP), 20% fulfilled these criteria but never developed AP.1 We confirm that 2 of 3 patients with anti-N-methyl-
中文翻译:
作者回应:首发精神病的临床、神经免疫学和脑脊液调查
我们感谢大家对我们的研究感兴趣。1根据 Pollak 及其同事的说法,如果患者具有突然发作的精神病症状并具有以下至少一项,则符合可能的自身免疫性精神病 (AP) 的2 个标准:存在肿瘤、运动障碍(运动障碍、紧张症)、不良反应抗精神病药,“严重或不成比例的”认知功能障碍,意识水平下降,不明原因的癫痫发作和显着的自主神经功能障碍。2满足这些标准应进行额外的测试,例如 EEG、MRI 和血清或脑脊液检查。在我们的 105 名首次精神病发作 (FEP) 患者的系列中,20% 符合这些标准但从未发展为 AP。1 我们确认 3 名患者中有 2 名患有抗 N-甲基-