An efficient construction of oxazoline-containing polycyclic scaffolds is presented through a Pd-catalyzed addition/cyclization of (hetero)arene tethered O-acyl cyanohydrin units and arylboronic acids. Diverse oxazoline-containing polycyclic compounds can be prepared in good to high yields under mild reaction conditions. This method can be extended to prepare multi-substituted polycyclic heterocyclic compounds via a Pd-catalyzed addition/cyclization/arylation tandem sequence using arylboronic acid and different heteroarene scaffolds such as thiophene, pyrrole and furan analogues.

中文翻译：

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通过腈和芳基硼酸的串联加成/环化，钯催化直接构建含恶唑啉的多环支架

通过（杂）芳烃系链的O-酰基氰醇单元和芳基硼酸的 Pd 催化加成/环化，提出了一种含恶唑啉的多环支架的有效构建。在温和的反应条件下，可以以良好到高的收率制备各种含恶唑啉的多环化合物。该方法可以扩展为使用芳基硼酸和不同的杂芳烃支架，如噻吩、吡咯和呋喃类似物，通过Pd 催化的加成/环化/芳基化串联序列制备多取代的多环杂环化合物。