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Optical angiography for diabetes-induced pathological changes in microvascular structure and function: An overview
Journal of Innovative Optical Health Sciences ( IF 2.5 ) Pub Date : 2021-11-19
Jingtan Zhu, Dongyu Li, Tingting Yu, Dan Zhu

Diabetes mellitus (DM) is a kind of metabolic disorder characterized by chronic hyperglycemia and glucose intolerance due to absolute or relative lack of insulin, leading to chronic damage of vasculature within various organ systems. These detrimental effects on the vascular networks will result in the development of various diseases associated with microvascular injury. Modern optical imaging techniques provide essential tools for accurate evaluation of the structural and functional changes of blood vessels down to capillaries level, which can offer valuable insight on understanding the development of DM-associated complications and design of targeted therapy. This review will briefly introduce the DM-induced structural and functional alterations of vasculature within different organs such as skin, cerebrum and kidneys, as well as how novel optical imaging techniques facilitate the studies focusing on exploration of these pathological changes of vasculature caused by DM both in-vivo and ex-vivo.



中文翻译:

糖尿病引起的微血管结构和功能病理变化的光学血管造影:概述

糖尿病(diabetes mellitus, DM)是由于胰岛素绝对或相对缺乏引起的以慢性高血糖和葡萄糖耐受不良为特征的代谢紊乱,导致各器官系统血管系统慢性损伤。这些对血管网络的不利影响将导致与微血管损伤相关的各种疾病的发展。现代光学成像技术为准确评估血管的结构和功能变化到毛细血管水平提供了必不可少的工具,这可以为了解 DM 相关并发症的发展和靶向治疗的设计提供宝贵的见解。本综述将简要介绍 DM 诱导的不同器官(如皮肤、大脑和肾脏)内脉管系统的结构和功能改变,体内体外

更新日期:2021-11-22
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