Objective

To examine the differences in live birth rates (LBRs), with single embryo transfer (SET), using oocytes from program generated egg donors vs. commercial egg bank donors and other factors affecting LBRs using donor oocytes.

Design

Retrospective cohort study.

Setting

Not applicable.

Patient(s)

A total of 40,485 in vitro fertilization cycles using donor oocytes reported to the Society for Assisted Reproductive Technology registry in 2016–2018.

Intervention(s)

None.

Main Outcome Measure(s)

Live birth rate and cumulative LBR for SET using donor oocytes.

Result(s)

Multivariate results from the first SET from 19,128 cycles, including 15,429 from program generated egg donors and 3,699 from commercial egg banks, showed, when controlling for all other variables, the following: the LBR in the first SET cycle using commercial egg banks was 53.3% compared with 55.4% using program recruited egg donors (odds ratio [OR], 0.92); a reduction in the LBR with increasing recipient age, ages 40–44 years (OR, 0.80), 45–49 years (OR, 0.77), and >49 years (OR, 0.65); a steady decline in the LBR with increases in recipient body mass index above normal; and a steady increase in the LBR in association with >16 oocytes retrieved. Double embryo transfer increased the LBR (SET, 52%, vs. double embryo transfer, 58%) but also significantly increased the multiple pregnancy LBR, with 43% twins and 0.9% triplets. Blastocyst transfer had a higher LBR than cleavage stage embryos (52.5% vs. 39.5%). Intracytoplasmic sperm injection vs. conventional insemination when using fresh oocytes from program donors had similar LBRs.

Conclusion(s)

When performing in vitro fertilization using donor oocytes with SET, the LBR is affected by oocyte source, recipient age, recipient body mass index, stage of embryo at transfer, and number of oocytes retrieved.

中文翻译：

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影响商业卵子库捐赠卵母细胞与计划卵子捐赠者活产率的因素：对 2016-2018 年辅助生殖技术协会登记处的 40,485 个周期的分析

客观的

为了检查活产率 (LBR) 和单胚胎移植 (SET) 的差异，使用来自程序生成的卵子供体与商业卵子库供体的卵母细胞以及影响使用供体卵母细胞的 LBR 的其他因素。

设计

回顾性队列研究。

环境

不适用。

耐心）

2016-2018 年，向辅助生殖技术协会登记处报告了总共 40,485 个使用供体卵母细胞的体外受精周期。

干预措施

没有。

主要观察指标）

使用供体卵母细胞进行 SET 的活产率和累积 LBR。

结果）

来自 19,128 个周期的第一个 SET 的多变量结果，包括来自计划生成的卵子捐赠者的 15,429 个和来自商业卵子库的 3,699 个，显示，在控制所有其他变量时，如下：使用商业卵子库的第一个 SET 周期中的 LBR 为 53.3%与使用计划招募卵子捐赠者的 55.4% 相比（优势比 [OR]，0.92）；LBR 随着受者年龄、40-44 岁 (OR, 0.80)、45-49 岁 (OR, 0.77) 和 >49 岁 (OR, 0.65) 的增加而降低；LBR 稳步下降，受者体重指数高于正常水平；并且 LBR 的稳定增加与 > 16 个卵母细胞的回收有关。双胚胎移植增加了 LBR（SET，52%，与双胚胎移植，58%），但也显着增加了多胎妊娠 LBR，双胞胎和三胞胎分别为 43% 和 0.9%。囊胚移植的 LBR 高于卵裂期胚胎（52.5% 对 39.5%）。当使用来自计划供体的新鲜卵母细胞时，胞浆内精子注射与常规授精具有相似的 LBR。

结论

当使用带有 SET 的供体卵母细胞进行体外受精时，LBR 受卵母细胞来源、受体年龄、受体体重指数、移植胚胎阶段和取回的卵母细胞数量的影响。