Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcγ receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.

中文翻译：

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20年来登革热病毒的抗原进化

感染登革热病毒 1 至 4 (DENV1-4) 之一会诱导针对同型感染的保护性抗体。然而，登革热病毒的一个显着特征是能够利用预先存在的异型抗体来感染带有 Fcγ 受体的免疫细胞，从而导致更高的病毒载量和免疫病理学事件，从而加剧疾病。我们使用 1994 年至 2014 年间泰国曼谷的 1944 个测序分离株（348 株）来追踪每种 DENV 血清型的抗原动态，并与区域和全球 DENV 抗原多样性（64 株）进行比较。20年来，泰国的DENV血清型逐渐相互演化。然而，在短时间内，血清型的相似性增加，流行程度也相应变化。基因型内的抗原进化涉及两种类型的抗原变化（血清型内和血清型间）之间的权衡，而基因型替换导致远离所有血清型的抗原变化。这些发现为抗原进化的理论动态提供了见解。