Background

Nine core domains for tendinopathy have been identified. For Achilles tendinopathy there is large variation in outcome measures used, and how these fit into the core domains has not been investigated.

Objective

To identify all available outcome measures outcome measures used to assess the clinical phenotype of Achilles tendinopathy in prospective studies and to map the outcomes measures into predefined health-related core domains.

Design

Systematic review.

Data Sources

Embase, MEDLINE (Ovid), Web of Science, CINAHL, The Cochrane Library, SPORTDiscus and Google Scholar.

Eligibility Criteria for Selecting Studies

Clinical diagnosis of Achilles tendinopathy, sample size ≥ ten participants, age ≥ 16 years, and the study design was a randomized or non-randomized clinical trial, observational cohort, single-arm intervention, or case series.

Results

9376 studies were initially screened and 307 studies were finally included, totaling 13,248 participants. There were 233 (177 core domain) different outcome measures identified across all domains. For each core domain outcome measures were identified, with a range between 8 and 35 unique outcome measures utilized for each domain. The proportion of studies that included outcomes for predefined core domains ranged from 4% for the psychological factors domain to 72% for the disability domain.

Conclusion

233 unique outcome measures for Achilles tendinopathy were identified. Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures.

Prospero Registration

CRD42020156763.

中文翻译：

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ICON 2020—国际科学肌腱病研讨会共识：跟腱病临床试验中报告的结果测量的系统评价

背景

已经确定了肌腱病的九个核心领域。对于跟腱病，所使用的结果测量存在很大差异，并且尚未研究这些如何适应核心领域。

客观的

确定前瞻性研究中用于评估跟腱病临床表型的所有可用结果测量，并将结果测量映射到预定义的健康相关核心领域。

设计

系统审查。

数据源

Embase、MEDLINE (Ovid)、Web of Science、CINAHL、The Cochrane Library、SPORTDiscus 和 Google Scholar。

选择研究的资格标准

跟腱病的临床诊断，样本量 ≥ 10 名参与者，年龄 ≥ 16 岁，研究设计是随机或非随机临床试验、观察队列、单臂干预或病例系列。

结果

初步筛选了 9376 项研究，最终纳入了 307 项研究，共计 13,248 名受试者。在所有领域中确定了 233（177 个核心领域）不同的结果度量。确定了每个核心领域的成果衡量标准，每个领域使用 8 到 35 个独特的成果衡量标准。包括预定义核心领域结果的研究比例从心理因素领域的 4% 到残疾领域的 72% 不等。

结论

确定了 233 个针对跟腱病的独特结果测量值。最常见的是，结果测量用于残疾领域。很少使用评估心理因素的结果测量。为跟腱病制定核心结果集的下一步是让患者、临床医生和研究人员参与，以就关键结果指标达成共识。

普洛斯彼罗注册

CRD42020156763。