Nutrient excess induces mitochondrial dysfunction, which participates in obesity-related complications. Obesity also associates with high cardiac oxidative stress, which contributes to myocardial dysfunction. Crewe et al. recently evidenced the pivotal role of adipocyte-derived extracellular vesicles (EVs) in cardiac oxidative stress responses and revealed their unexpected protective effect against ischemia/reperfusion injury.

中文翻译：

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脂肪细胞胞外囊泡：心脏线粒体应激的拯救者

营养过剩会导致线粒体功能障碍，从而导致肥胖相关并发症。肥胖还与导致心肌功能障碍的高心脏氧化应激有关。克鲁等人。最近证明了脂肪细胞衍生的细胞外囊泡（EVs）在心脏氧化应激反应中的关键作用，并揭示了它们对缺血/再灌注损伤的意想不到的保护作用。