Numerous studies have demonstrated the importance of the adaptive immunity for survival following Ebola virus (EBOV) infection. To evaluate the contribution of tissue damage to EBOV-induced immune suppression, acute liver damage or hemolysis, 2 symptoms associated with lethal EBOV infection, were chemically induced in vaccinated mice. Results show that either liver damage or hemolysis was sufficient to inhibit the host humoral response against EBOV glycoprotein and to drastically reduce the level of circulating T cells. This study thus provides a possible mechanism for the limited specific antibody production and lymphopenia in individuals with lethal hemorrhagic fever infections.

中文翻译：

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短暂性肝损伤和溶血与埃博拉病毒糖蛋白特异性抗体反应和淋巴细胞减少的抑制有关

大量研究证明了适应性免疫对于埃博拉病毒（EBOV）感染后生存的重要性。为了评估组织损伤对埃博拉病毒引起的免疫抑制、急性肝损伤或溶血的影响，在接种疫苗的小鼠中通过化学方法诱导了两种与致命埃博拉病毒感染相关的症状。结果表明，肝损伤或溶血足以抑制宿主针对 EBOV 糖蛋白的体液反应，并大幅降低循环 T 细胞的水平。因此，这项研究为患有致命性出血热感染的个体中特异性抗体产生有限和淋巴细胞减少提供了可能的机制。